| pubmed-article:17949929 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17949929 | lifeskim:mentions | umls-concept:C0877851 | lld:lifeskim |
| pubmed-article:17949929 | lifeskim:mentions | umls-concept:C0003209 | lld:lifeskim |
| pubmed-article:17949929 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:17949929 | lifeskim:mentions | umls-concept:C1515999 | lld:lifeskim |
| pubmed-article:17949929 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17949929 | pubmed:dateCreated | 2007-12-6 | lld:pubmed |
| pubmed-article:17949929 | pubmed:abstractText | Taraxacum officinale has been widely used as a folkloric medicine for the treatment of diverse diseases. The dried plant was extracted with 70% ethanol to generate its ethanol extract (TEE). For some experiments, ethyl acetate (EA), n-butanol (BuOH) and aqueous (Aq) fractions were prepared in succession from TEE. TEE showed a scavenging activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, a diminishing effect on intracellular reactive oxygen species (ROS) level, and an anti-angiogenic activity in the chicken chorioallantoic (CAM) assay. In the carrageenan-induced air pouch model, TEE inhibited production of exudate, and significantly diminished nitric oxide (NO) and leukocyte levels in the exudate. It also possessed an inhibitory effect on acetic acid-induced vascular permeability and caused a dose-dependent inhibition on acetic acid-induced abdominal writhing in mice. Suppressive effects of TEE on the production of NO and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-stimulated macrophages were also assessed. Among the fractions, the n-butanol fraction (BuOH) was identified to be most effective in the CAM assay. Collectively, Taraxacum officinale contains anti-angiogenic, anti-inflammatory and anti-nociceptive activities through its inhibition of NO production and COX-2 expression and/or its antioxidative activity. | lld:pubmed |
| pubmed-article:17949929 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17949929 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17949929 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17949929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17949929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17949929 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17949929 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17949929 | pubmed:issn | 0378-8741 | lld:pubmed |
| pubmed-article:17949929 | pubmed:author | pubmed-author:ParkEun-HeeEH | lld:pubmed |
| pubmed-article:17949929 | pubmed:author | pubmed-author:LimChang-JinC... | lld:pubmed |
| pubmed-article:17949929 | pubmed:author | pubmed-author:KimYoung-Myeo... | lld:pubmed |
| pubmed-article:17949929 | pubmed:author | pubmed-author:KangYoung-Soo... | lld:pubmed |
| pubmed-article:17949929 | pubmed:author | pubmed-author:KangHyun-Jung... | lld:pubmed |
| pubmed-article:17949929 | pubmed:author | pubmed-author:JungHyun-JooH... | lld:pubmed |
| pubmed-article:17949929 | pubmed:author | pubmed-author:JeonHye-JinHJ | lld:pubmed |
| pubmed-article:17949929 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17949929 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:17949929 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:17949929 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17949929 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17949929 | pubmed:pagination | 82-8 | lld:pubmed |
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| pubmed-article:17949929 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17949929 | pubmed:articleTitle | Anti-inflammatory activity of Taraxacum officinale. | lld:pubmed |
| pubmed-article:17949929 | pubmed:affiliation | College of Pharmacy, Sookmyung Women's University, Cheongpa-dong, Yongsan-ku, Seoul 140-742, Republic of Korea. | lld:pubmed |
| pubmed-article:17949929 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17949929 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17949929 | lld:pubmed |
