| pubmed-article:17948054 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17948054 | lifeskim:mentions | umls-concept:C0085187 | lld:lifeskim |
| pubmed-article:17948054 | lifeskim:mentions | umls-concept:C1326912 | lld:lifeskim |
| pubmed-article:17948054 | lifeskim:mentions | umls-concept:C1155291 | lld:lifeskim |
| pubmed-article:17948054 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:17948054 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:17948054 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:17948054 | pubmed:dateCreated | 2007-11-16 | lld:pubmed |
| pubmed-article:17948054 | pubmed:abstractText | The POT1 (protection of telomeres) protein binds the single-stranded G-rich overhang and is essential for both telomere end protection and telomere length regulation. Telomeric binding of POT1 is enhanced by its interaction with TPP1. In this study, we demonstrate that mouse Tpp1 confers telomere end protection by recruiting Pot1a and Pot1b to telomeres. Knockdown of Tpp1 elicits a p53-dependent growth arrest and an ATM-dependent DNA damage response at telomeres. In contrast to depletion of Trf2, which activates ATM, removal of Pot1a and Pot1b from telomeres initiates an ATR-dependent DNA damage response (DDR). Finally, we show that telomere dysfunction as a result of Tpp1 depletion promotes chromosomal instability and tumorigenesis in the absence of an ATM-dependent DDR. Our results uncover a novel ATR-dependent DDR at telomeres that is normally shielded by POT1 binding to the single-stranded G-overhang. In addition, our results suggest that loss of ATM can cooperate with dysfunctional telomeres to promote cellular transformation and tumor formation in vivo. | lld:pubmed |
| pubmed-article:17948054 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17948054 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17948054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17948054 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17948054 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17948054 | pubmed:issn | 1460-2075 | lld:pubmed |
| pubmed-article:17948054 | pubmed:author | pubmed-author:DengYibinY | lld:pubmed |
| pubmed-article:17948054 | pubmed:author | pubmed-author:LinYahongY | lld:pubmed |
| pubmed-article:17948054 | pubmed:author | pubmed-author:BrownEric JEJ | lld:pubmed |
| pubmed-article:17948054 | pubmed:author | pubmed-author:HeHuaH | lld:pubmed |
| pubmed-article:17948054 | pubmed:author | pubmed-author:ChanSuzanneS | lld:pubmed |
| pubmed-article:17948054 | pubmed:author | pubmed-author:YuanGuohuaG | lld:pubmed |
| pubmed-article:17948054 | pubmed:author | pubmed-author:ChangSandyS | lld:pubmed |
| pubmed-article:17948054 | pubmed:author | pubmed-author:Cosme-BlancoW... | lld:pubmed |
| pubmed-article:17948054 | pubmed:author | pubmed-author:GuoXiaolanX | lld:pubmed |
| pubmed-article:17948054 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17948054 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:17948054 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:17948054 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17948054 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17948054 | pubmed:pagination | 4709-19 | lld:pubmed |
| pubmed-article:17948054 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
