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pubmed-article:17947486pubmed:abstractTextTo assess the safety and tolerability, pharmacokinetics, and early evidence of antitumor activity of escalating doses of lexatumumab (HGS-ETR2), a fully human agonistic monoclonal antibody which targets and activates the tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) in patients with advanced solid malignancies.lld:pubmed
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pubmed-article:17947486pubmed:affiliationNorthern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom. Ruth.Plummer@newcastle.ac.uklld:pubmed
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