Linked Life Data

17942895

Source:http://linkedlifedata.com/resource/pubmed/id/17942895

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:17942895rdf:typepubmed:Citationlld:pubmed
pubmed-article:17942895lifeskim:mentionsumls-concept:C1458155lld:lifeskim
pubmed-article:17942895lifeskim:mentionsumls-concept:C0041904lld:lifeskim
pubmed-article:17942895lifeskim:mentionsumls-concept:C0542341lld:lifeskim
pubmed-article:17942895lifeskim:mentionsumls-concept:C0376571lld:lifeskim
pubmed-article:17942895lifeskim:mentionsumls-concept:C0162493lld:lifeskim
pubmed-article:17942895lifeskim:mentionsumls-concept:C1419240lld:lifeskim
pubmed-article:17942895lifeskim:mentionsumls-concept:C0741847lld:lifeskim
pubmed-article:17942895lifeskim:mentionsumls-concept:C0205214lld:lifeskim
pubmed-article:17942895lifeskim:mentionsumls-concept:C2348519lld:lifeskim
pubmed-article:17942895pubmed:issue20lld:pubmed
pubmed-article:17942895pubmed:dateCreated2007-10-18lld:pubmed
pubmed-article:17942895pubmed:abstractTextThe breast cancer susceptibility gene BRCA1 encodes a large protein thought to contribute to a variety of cellular processes, although the critical determinants of BRCA1-deficient tumorigenesis remain unclear. Given that BRCA1 is required for cell proliferation, suppressor mutations are believed to modify BRCA1 phenotypes and contribute to the etiology of BRCA1-deficient tumors. Here, we show that overexpression of the homologous recombinase RAD51 in a DT40 BRCA1Delta/Delta mutant rescues defects in proliferation, DNA damage survival, and homologous recombination (HR). In addition, epistasis analysis with BRCA1 and the DNA end-joining factor KU70 indicates that these factors operate independently of one another to repair double-strand breaks. Consistent with this genetic finding, cell synchronization studies show that the ability of BRCA1 to promote radioresistance is restricted to the late S and G2 phases of the cell cycle, as predicted for genes whose function is specific to homology-mediated repair rather than nonhomologous end-joining. Notably, retrospective analyses of microarray expression data reveal elevated expression of RAD51 and two of its late-acting cofactors, RAD54 and RAD51AP1, in BRCA1-deficient versus sporadic breast tumors. Taken together, our results indicate that up-regulation of HR provides a permissive genetic context for cells lacking BRCA1 function by circumventing its requirement in RAD51 subnuclear assembly. Furthermore, the data support a model in which enhanced HR activity contributes to the etiology of BRCA1-deficient tumors.lld:pubmed
pubmed-article:17942895pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17942895pubmed:languageenglld:pubmed
pubmed-article:17942895pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17942895pubmed:citationSubsetIMlld:pubmed
pubmed-article:17942895pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17942895pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17942895pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17942895pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17942895pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17942895pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17942895pubmed:statusMEDLINElld:pubmed
pubmed-article:17942895pubmed:monthOctlld:pubmed
pubmed-article:17942895pubmed:issn0008-5472lld:pubmed
pubmed-article:17942895pubmed:authorpubmed-author:YamazoeMitsuy...lld:pubmed
pubmed-article:17942895pubmed:authorpubmed-author:TakedaShunich...lld:pubmed
pubmed-article:17942895pubmed:authorpubmed-author:MartinRichard...lld:pubmed
pubmed-article:17942895pubmed:authorpubmed-author:BishopDouglas...lld:pubmed
pubmed-article:17942895pubmed:authorpubmed-author:MinnAndy JAJlld:pubmed
pubmed-article:17942895pubmed:authorpubmed-author:OrelliBrian...lld:pubmed
pubmed-article:17942895pubmed:issnTypePrintlld:pubmed
pubmed-article:17942895pubmed:day15lld:pubmed
pubmed-article:17942895pubmed:volume67lld:pubmed
pubmed-article:17942895pubmed:ownerNLMlld:pubmed
pubmed-article:17942895pubmed:authorsCompleteYlld:pubmed
pubmed-article:17942895pubmed:pagination9658-65lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:meshHeadingpubmed-meshheading:17942895...lld:pubmed
pubmed-article:17942895pubmed:year2007lld:pubmed
pubmed-article:17942895pubmed:articleTitleRAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors.lld:pubmed
pubmed-article:17942895pubmed:affiliationDepartment of Radiation, Ludwig Center for Metastasis Research, University of Chicago, Chicago, Illinois 60637, USA.lld:pubmed
pubmed-article:17942895pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17942895pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
entrez-gene:672entrezgene:pubmedpubmed-article:17942895lld:entrezgene
entrez-gene:5888entrezgene:pubmedpubmed-article:17942895lld:entrezgene
entrez-gene:499870entrezgene:pubmedpubmed-article:17942895lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:17942895lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:17942895lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17942895lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17942895lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17942895lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17942895lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17942895lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17942895lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17942895lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17942895lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17942895lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17942895lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17942895lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17942895lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17942895lld:pubmed