| pubmed-article:17937676 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17937676 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:17937676 | lifeskim:mentions | umls-concept:C0150369 | lld:lifeskim |
| pubmed-article:17937676 | lifeskim:mentions | umls-concept:C0023343 | lld:lifeskim |
| pubmed-article:17937676 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:17937676 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:17937676 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:17937676 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:17937676 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:17937676 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:17937676 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:17937676 | lifeskim:mentions | umls-concept:C0333516 | lld:lifeskim |
| pubmed-article:17937676 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:17937676 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:17937676 | lifeskim:mentions | umls-concept:C1326120 | lld:lifeskim |
| pubmed-article:17937676 | lifeskim:mentions | umls-concept:C2745888 | lld:lifeskim |
| pubmed-article:17937676 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17937676 | pubmed:dateCreated | 2007-10-16 | lld:pubmed |
| pubmed-article:17937676 | pubmed:abstractText | Identifying pathogen and host-related laboratory parameters are essential for the early diagnosis of leprosy reactions. The present study aimed to clarify the validity of measuring the profiles of serum cytokines [interleukin (IL)-4, IL-6, IL-10, interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha], the soluble IL-6 receptor (sIL-6R), soluble T cell (sCD27) and macrophage (neopterin) activation markers and Mycobacterium leprae-specific anti-PGL-I IgM antibodies in relation to the leprosy spectrum and reactions. Serum samples from 131 Indonesian leprosy patients (82 non-reactional leprosy patients and 49 reactional) and 112 healthy controls (HC) from the same endemic region were investigated. Forty-four (89.8%) of the reactional patients had erythema nodosum leprosum (ENL) while only five (10.2%) had reversal reaction (RR). Follow-up serum samples after corticosteroid treatment were also obtained from 17 of the patients with ENL and one with RR. A wide variability in cytokine levels was observed in the patient groups. However, IFN-gamma and sIL-6R were elevated significantly in ENL compared to non-ENL patients. Levels of IFN-gamma, TNF-alpha and sIL-6R declined significantly upon corticosteroid treatment of ENL. Thus, although the present study suggests limited applicability of serial measurement of IFN-gamma, TNF-alpha and sIL-6R in monitoring treatment efficacy of ENL, reactions it recommends a search for a wider panel of more disease-specific markers in future studies. | lld:pubmed |
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| pubmed-article:17937676 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17937676 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17937676 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17937676 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17937676 | pubmed:issn | 1365-2249 | lld:pubmed |
| pubmed-article:17937676 | pubmed:author | pubmed-author:DaoTT | lld:pubmed |
| pubmed-article:17937676 | pubmed:author | pubmed-author:HattaMM | lld:pubmed |
| pubmed-article:17937676 | pubmed:author | pubmed-author:IyerAA | lld:pubmed |
| pubmed-article:17937676 | pubmed:author | pubmed-author:OskamLL | lld:pubmed |
| pubmed-article:17937676 | pubmed:author | pubmed-author:GelukAA | lld:pubmed |
| pubmed-article:17937676 | pubmed:author | pubmed-author:FaberWW | lld:pubmed |
| pubmed-article:17937676 | pubmed:author | pubmed-author:LuitenSS | lld:pubmed |
| pubmed-article:17937676 | pubmed:author | pubmed-author:UsmanRR | lld:pubmed |
| pubmed-article:17937676 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17937676 | pubmed:volume | 150 | lld:pubmed |
| pubmed-article:17937676 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17937676 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17937676 | pubmed:pagination | 210-6 | lld:pubmed |
| pubmed-article:17937676 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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