| pubmed-article:17932106 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17932106 | lifeskim:mentions | umls-concept:C0034804 | lld:lifeskim |
| pubmed-article:17932106 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:17932106 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:17932106 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:17932106 | lifeskim:mentions | umls-concept:C0301039 | lld:lifeskim |
| pubmed-article:17932106 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17932106 | pubmed:dateCreated | 2008-1-28 | lld:pubmed |
| pubmed-article:17932106 | pubmed:abstractText | The estrogen receptor (ER) protects against debilitating effects of the inflammatory response by inhibiting the proinflammatory transcription factor nuclear factor-kappaB (NFkappaB). Heretofore cAMP response element-binding protein (CREB)-binding protein (CBP) has been suggested to mediate inhibitory cross talk by functioning either as a scaffold that links ER and NFkappaB or as a required cofactor that competitively binds to one or the other transcriptional factor. However, here we demonstrate that ER is recruited to the NFkappaB response element of the MCP-1 (monocyte chemoattractant protein-1) and IL-8 promoters and displaces CBP, but not p65, in the MCF-7 breast cancer cell line. In contrast, ER displaced p65 and associated coregulators from the IL-6 promoter, demonstrating a gene-specific role for CBP in integrating inflammatory and steroid signaling. Further, RNA interference and overexpression studies demonstrated that CBP dosage regulates estrogen-mediated suppression of MCP-1 and IL-8, but not IL-6, gene expression. This work further demonstrates that CBP dosage is a critical regulator of gene-specific signal integration between the ER- and NFkappaB-signaling pathways. | lld:pubmed |
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| pubmed-article:17932106 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17932106 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17932106 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17932106 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17932106 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17932106 | pubmed:issn | 0888-8809 | lld:pubmed |
| pubmed-article:17932106 | pubmed:author | pubmed-author:NettlesKendal... | lld:pubmed |
| pubmed-article:17932106 | pubmed:author | pubmed-author:GreeneGeoffre... | lld:pubmed |
| pubmed-article:17932106 | pubmed:author | pubmed-author:MétivierRapha... | lld:pubmed |
| pubmed-article:17932106 | pubmed:author | pubmed-author:GilGermanG | lld:pubmed |
| pubmed-article:17932106 | pubmed:author | pubmed-author:NowakJasonJ | lld:pubmed |
| pubmed-article:17932106 | pubmed:author | pubmed-author:SharmaVandana... | lld:pubmed |
| pubmed-article:17932106 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17932106 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:17932106 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17932106 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17932106 | pubmed:pagination | 263-72 | lld:pubmed |
| pubmed-article:17932106 | pubmed:dateRevised | 2010-9-14 | lld:pubmed |
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| pubmed-article:17932106 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17932106 | pubmed:articleTitle | CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor. | lld:pubmed |
| pubmed-article:17932106 | pubmed:affiliation | Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL 33458, USA. knettles@scripps.edu | lld:pubmed |
| pubmed-article:17932106 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17932106 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:17932106 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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