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pubmed-article:17931866pubmed:abstractTextReplacement of the hydroxy cyclopentanone ring in PGE(2) with chemically more stable heterocyclic rings and substitution of the unsaturated alpha-alkenyl chain with a metabolically more stable phenethyl chain led to the development of potent and selective analogs of PGE(2). Compound 10f showed the highest potency and selectivity for EP(4) the receptor.lld:pubmed
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pubmed-article:17931866pubmed:articleTitleSynthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists.lld:pubmed
pubmed-article:17931866pubmed:affiliationDepartment of Medicinal Chemistry, EMD-Serono Research Institute, Inc., Rockland, MA 02370, USA. zhong.zhao@genzyme.comlld:pubmed
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