Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:17911624rdf:typepubmed:Citationlld:pubmed
pubmed-article:17911624lifeskim:mentionsumls-concept:C0004611lld:lifeskim
pubmed-article:17911624lifeskim:mentionsumls-concept:C0330390lld:lifeskim
pubmed-article:17911624lifeskim:mentionsumls-concept:C1273518lld:lifeskim
pubmed-article:17911624lifeskim:mentionsumls-concept:C0031150lld:lifeskim
pubmed-article:17911624lifeskim:mentionsumls-concept:C0024432lld:lifeskim
pubmed-article:17911624lifeskim:mentionsumls-concept:C0178719lld:lifeskim
pubmed-article:17911624lifeskim:mentionsumls-concept:C0108685lld:lifeskim
pubmed-article:17911624lifeskim:mentionsumls-concept:C0597298lld:lifeskim
pubmed-article:17911624lifeskim:mentionsumls-concept:C1413323lld:lifeskim
pubmed-article:17911624lifeskim:mentionsumls-concept:C0920532lld:lifeskim
pubmed-article:17911624lifeskim:mentionsumls-concept:C0162388lld:lifeskim
pubmed-article:17911624lifeskim:mentionsumls-concept:C1879547lld:lifeskim
pubmed-article:17911624lifeskim:mentionsumls-concept:C0205224lld:lifeskim
pubmed-article:17911624pubmed:issue8lld:pubmed
pubmed-article:17911624pubmed:dateCreated2007-10-3lld:pubmed
pubmed-article:17911624pubmed:abstractTextThe C/ebpb gene is translated into three different protein isoforms, two transcriptional activating proteins (38-kDa Full and 34-kDa liver-enriched transcriptional activation protein (LAP)) and one transcriptional inhibitory protein, by alternative use of different AUG initiation codons within the same open reading frame. The isoform 34-kDa LAP is thought to be the most transcriptionally active form of C/EBPbeta in macrophages. To assess the function of the 34-kDa LAP in vivo, we generated knock-in mice, in which methionine 20 of C/EBPbeta, the start site for the 34-kDa LAP is replaced with an alanine. The expression of the 34-kDa LAP was abolished in C/ebpb(M20A/M20A) mice. The induction of C/EBPbeta target genes, such as inflammatory cytokines, chemokines, prostanoid synthetase, and antimicrobial peptides, was abolished in C/ebpb(M20A/M20A) macrophages, and C/ebpb(M20A/M20A) mice were susceptible to Listeria monocytogenes infection. Furthermore, the heat-killed Propionibacterium acnes-induced Th1 response, granuloma formation, and LPS shock were severely impaired. Nevertheless, impairment of intracellular bacteria killing, which is the most prominent phenotype in C/EBPbeta-deficient mice, was not observed in C/ebpb(M20A/M20A) mice. Collectively, we demonstrated that 34-kDa LAP is responsible for NF-IL6-mediated gene induction, but not essential for intracellular bacteria killing in activated macrophages.lld:pubmed
pubmed-article:17911624pubmed:languageenglld:pubmed
pubmed-article:17911624pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17911624pubmed:citationSubsetAIMlld:pubmed
pubmed-article:17911624pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17911624pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17911624pubmed:statusMEDLINElld:pubmed
pubmed-article:17911624pubmed:monthOctlld:pubmed
pubmed-article:17911624pubmed:issn0022-1767lld:pubmed
pubmed-article:17911624pubmed:authorpubmed-author:AkiraShizuoSlld:pubmed
pubmed-article:17911624pubmed:authorpubmed-author:TanakaTakashi...lld:pubmed
pubmed-article:17911624pubmed:authorpubmed-author:YamamotoMasah...lld:pubmed
pubmed-article:17911624pubmed:authorpubmed-author:KaishoTsuneya...lld:pubmed
pubmed-article:17911624pubmed:authorpubmed-author:MatsumotoMako...lld:pubmed
pubmed-article:17911624pubmed:authorpubmed-author:YoshimoriTamo...lld:pubmed
pubmed-article:17911624pubmed:authorpubmed-author:UematsuSatosh...lld:pubmed
pubmed-article:17911624pubmed:authorpubmed-author:YamakamiMegum...lld:pubmed
pubmed-article:17911624pubmed:authorpubmed-author:OmoriHirokoHlld:pubmed
pubmed-article:17911624pubmed:issnTypePrintlld:pubmed
pubmed-article:17911624pubmed:day15lld:pubmed
pubmed-article:17911624pubmed:volume179lld:pubmed
pubmed-article:17911624pubmed:ownerNLMlld:pubmed
pubmed-article:17911624pubmed:authorsCompleteYlld:pubmed
pubmed-article:17911624pubmed:pagination5378-86lld:pubmed
pubmed-article:17911624pubmed:dateRevised2008-11-21lld:pubmed
pubmed-article:17911624pubmed:meshHeadingpubmed-meshheading:17911624...lld:pubmed
pubmed-article:17911624pubmed:meshHeadingpubmed-meshheading:17911624...lld:pubmed
pubmed-article:17911624pubmed:meshHeadingpubmed-meshheading:17911624...lld:pubmed
pubmed-article:17911624pubmed:meshHeadingpubmed-meshheading:17911624...lld:pubmed
pubmed-article:17911624pubmed:meshHeadingpubmed-meshheading:17911624...lld:pubmed
pubmed-article:17911624pubmed:meshHeadingpubmed-meshheading:17911624...lld:pubmed
pubmed-article:17911624pubmed:meshHeadingpubmed-meshheading:17911624...lld:pubmed
pubmed-article:17911624pubmed:meshHeadingpubmed-meshheading:17911624...lld:pubmed
pubmed-article:17911624pubmed:meshHeadingpubmed-meshheading:17911624...lld:pubmed
pubmed-article:17911624pubmed:meshHeadingpubmed-meshheading:17911624...lld:pubmed
pubmed-article:17911624pubmed:meshHeadingpubmed-meshheading:17911624...lld:pubmed
pubmed-article:17911624pubmed:meshHeadingpubmed-meshheading:17911624...lld:pubmed
pubmed-article:17911624pubmed:meshHeadingpubmed-meshheading:17911624...lld:pubmed
pubmed-article:17911624pubmed:meshHeadingpubmed-meshheading:17911624...lld:pubmed
pubmed-article:17911624pubmed:meshHeadingpubmed-meshheading:17911624...lld:pubmed
pubmed-article:17911624pubmed:year2007lld:pubmed
pubmed-article:17911624pubmed:articleTitleThe C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing.lld:pubmed
pubmed-article:17911624pubmed:affiliationDepartment of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan.lld:pubmed
pubmed-article:17911624pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17911624pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:17911624pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:12608entrezgene:pubmedpubmed-article:17911624lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:17911624lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17911624lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17911624lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17911624lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17911624lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17911624lld:pubmed