| pubmed-article:17906695 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17906695 | lifeskim:mentions | umls-concept:C0965644 | lld:lifeskim |
| pubmed-article:17906695 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:17906695 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:17906695 | lifeskim:mentions | umls-concept:C1413430 | lld:lifeskim |
| pubmed-article:17906695 | lifeskim:mentions | umls-concept:C1333897 | lld:lifeskim |
| pubmed-article:17906695 | lifeskim:mentions | umls-concept:C1704838 | lld:lifeskim |
| pubmed-article:17906695 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:17906695 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:17906695 | lifeskim:mentions | umls-concept:C1514526 | lld:lifeskim |
| pubmed-article:17906695 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:17906695 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:17906695 | pubmed:dateCreated | 2008-3-20 | lld:pubmed |
| pubmed-article:17906695 | pubmed:abstractText | Hypoxia-inducible factor-1alpha (HIF-1alpha) is destabilized via the ubiquitin-proteasome system. Thus HIF-1alpha expression is robustly upregulated by proteasome inhibition, but paradoxically its activity is reduced. In the present study, we investigated the mechanism underlying the paradoxical response of HIF-1alpha to proteasome inhibition. In both Hep3B and HEK293 cells, a proteasome inhibitor MG132 noticeably attenuated hypoxic induction of erythropoietin and VEGF mRNAs. MG132 inactivated HIF-1alpha C-terminal transactivation domain (CAD), independently of factor inhibiting HIF-1 (FIH) and inhibited p300 recruitment by HIF-1alpha. We next tested the possibility that CITED2 is involved in the HIF-1 inactivation. CITED2 was found to be degraded via the ubiquitin-proteasome system and thus was stabilized by proteasome inhibition. Both the activity and the p300 binding of HIF-1alpha were inhibited by CITED2 expression and recovered by CITED2 siRNA in the presence of MG132. These results suggest that CITED2 is stabilized by proteasome inhibition and inactivates HIF-1 by interfering with the HIF-1alpha-p300 interaction. This may be an important mode-of-action for proteasome inhibition-based cancer therapy. | lld:pubmed |
| pubmed-article:17906695 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17906695 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17906695 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17906695 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17906695 | pubmed:issn | 1476-5594 | lld:pubmed |
| pubmed-article:17906695 | pubmed:author | pubmed-author:ShinD HDH | lld:pubmed |
| pubmed-article:17906695 | pubmed:author | pubmed-author:LiS HSH | lld:pubmed |
| pubmed-article:17906695 | pubmed:author | pubmed-author:FeisHH | lld:pubmed |
| pubmed-article:17906695 | pubmed:author | pubmed-author:PaiR RRR | lld:pubmed |
| pubmed-article:17906695 | pubmed:author | pubmed-author:HuangL ELE | lld:pubmed |
| pubmed-article:17906695 | pubmed:author | pubmed-author:ParkJ-WJW | lld:pubmed |
| pubmed-article:17906695 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17906695 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:17906695 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:17906695 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17906695 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17906695 | pubmed:pagination | 1939-44 | lld:pubmed |
| pubmed-article:17906695 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:17906695 | pubmed:meshHeading | pubmed-meshheading:17906695... | lld:pubmed |
| pubmed-article:17906695 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17906695 | pubmed:articleTitle | CITED2 mediates the paradoxical responses of HIF-1alpha to proteasome inhibition. | lld:pubmed |
| pubmed-article:17906695 | pubmed:affiliation | Department of Pharmacology, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, Korea. | lld:pubmed |
| pubmed-article:17906695 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17906695 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:10370 | entrezgene:pubmed | pubmed-article:17906695 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17906695 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17906695 | lld:pubmed |
