| pubmed-article:17905650 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17905650 | lifeskim:mentions | umls-concept:C0024554 | lld:lifeskim |
| pubmed-article:17905650 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:17905650 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17905650 | lifeskim:mentions | umls-concept:C0015677 | lld:lifeskim |
| pubmed-article:17905650 | lifeskim:mentions | umls-concept:C0015695 | lld:lifeskim |
| pubmed-article:17905650 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:17905650 | lifeskim:mentions | umls-concept:C0163314 | lld:lifeskim |
| pubmed-article:17905650 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:17905650 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:17905650 | pubmed:dateCreated | 2007-10-8 | lld:pubmed |
| pubmed-article:17905650 | pubmed:abstractText | Mice lacking I-FABP (encoded by the Fabp2 gene) exhibit a gender dimorphic response to a high fat/cholesterol diet challenge characterized by hepatomegaly in male I-FABP-deficient mice. In this study, we determined if this gender-specific modification of liver mass in mice lacking I-FABP is attributable to the high fat content of the diet alone and whether hepatic Fabp1 gene (encodes L-FABP) expression contributes to this difference. Wild-type and Fabp2-/- mice of both genders were fed a diet enriched with either polyunsaturated or saturated fatty acids (PUFA or SFA, respectively) in the absence of cholesterol. Male Fabp2-/- mice, but not female Fabp2-/- mice, exhibited increased liver mass and hepatic triacylglycerol (TG) deposition as compared to corresponding wild-type mice. In wild-type mice that were fed the standard chow diet, there was no difference in the concentration of hepatic L-FABP protein between males and females although the loss of I-FABP did cause a slight reduction of hepatic L-FABP abundance in both genders. The hepatic L-FABP mRNA abundance in both male and female wild-type and Fabp2-/- mice was higher in the PUFA-fed group than in the SFA-fed group, and was correlated with L-FABP protein abundance. No correlation between hepatic L-FABP protein abundance and hepatic TG concentration was found. The results obtained demonstrate that loss of I-FABP renders male mice sensitive to high fat diet-induced fatty liver, and this effect is independent of hepatic L-FABP. | lld:pubmed |
| pubmed-article:17905650 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17905650 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17905650 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17905650 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17905650 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17905650 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17905650 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17905650 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17905650 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17905650 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:17905650 | pubmed:author | pubmed-author:AgellonLuis... | lld:pubmed |
| pubmed-article:17905650 | pubmed:author | pubmed-author:ThomsonAlan... | lld:pubmed |
| pubmed-article:17905650 | pubmed:author | pubmed-author:UwieraRichard... | lld:pubmed |
| pubmed-article:17905650 | pubmed:author | pubmed-author:LuongLeL | lld:pubmed |
| pubmed-article:17905650 | pubmed:author | pubmed-author:TothMatthew... | lld:pubmed |
| pubmed-article:17905650 | pubmed:author | pubmed-author:DrozdowskiLau... | lld:pubmed |
| pubmed-article:17905650 | pubmed:author | pubmed-author:IordacheClaud... | lld:pubmed |
| pubmed-article:17905650 | pubmed:author | pubmed-author:ClandininM... | lld:pubmed |
| pubmed-article:17905650 | pubmed:author | pubmed-author:LiLenaL | lld:pubmed |
| pubmed-article:17905650 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17905650 | pubmed:volume | 1771 | lld:pubmed |
| pubmed-article:17905650 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17905650 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17905650 | pubmed:pagination | 1283-8 | lld:pubmed |
| pubmed-article:17905650 | pubmed:meshHeading | pubmed-meshheading:17905650... | lld:pubmed |
| pubmed-article:17905650 | pubmed:meshHeading | pubmed-meshheading:17905650... | lld:pubmed |
| pubmed-article:17905650 | pubmed:meshHeading | pubmed-meshheading:17905650... | lld:pubmed |
| pubmed-article:17905650 | pubmed:meshHeading | pubmed-meshheading:17905650... | lld:pubmed |
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| pubmed-article:17905650 | pubmed:meshHeading | pubmed-meshheading:17905650... | lld:pubmed |
| pubmed-article:17905650 | pubmed:meshHeading | pubmed-meshheading:17905650... | lld:pubmed |
| pubmed-article:17905650 | pubmed:meshHeading | pubmed-meshheading:17905650... | lld:pubmed |
| pubmed-article:17905650 | pubmed:meshHeading | pubmed-meshheading:17905650... | lld:pubmed |
| pubmed-article:17905650 | pubmed:meshHeading | pubmed-meshheading:17905650... | lld:pubmed |
| pubmed-article:17905650 | pubmed:meshHeading | pubmed-meshheading:17905650... | lld:pubmed |
| pubmed-article:17905650 | pubmed:meshHeading | pubmed-meshheading:17905650... | lld:pubmed |
| pubmed-article:17905650 | pubmed:meshHeading | pubmed-meshheading:17905650... | lld:pubmed |
| pubmed-article:17905650 | pubmed:meshHeading | pubmed-meshheading:17905650... | lld:pubmed |
| pubmed-article:17905650 | pubmed:meshHeading | pubmed-meshheading:17905650... | lld:pubmed |
| pubmed-article:17905650 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17905650 | pubmed:articleTitle | Loss of intestinal fatty acid binding protein increases the susceptibility of male mice to high fat diet-induced fatty liver. | lld:pubmed |
| pubmed-article:17905650 | pubmed:affiliation | Canadian Institutes of Health Research Molecular and Cell Biology of Lipids Research Group and Department of Biochemistry, University of Alberta, Edmonton, AB, Canada T6G 2S2. luis.agellon@mcgill.ca | lld:pubmed |
| pubmed-article:17905650 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17905650 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:14079 | entrezgene:pubmed | pubmed-article:17905650 | lld:entrezgene |
| entrez-gene:14080 | entrezgene:pubmed | pubmed-article:17905650 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17905650 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17905650 | lld:entrezgene |
