| pubmed-article:17900896 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17900896 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:17900896 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:17900896 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:17900896 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:17900896 | lifeskim:mentions | umls-concept:C0216510 | lld:lifeskim |
| pubmed-article:17900896 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:17900896 | pubmed:dateCreated | 2007-10-16 | lld:pubmed |
| pubmed-article:17900896 | pubmed:abstractText | From HTS lead 1, a novel benzoisoquinolinone class of ATP-competitive Chk1 inhibitors was devised and synthesized via a photochemical route. Using X-ray crystallography as a guide, potency was rapidly enhanced through the installation of a tethered basic amine designed to interact with an acidic residue (Glu91) in the enzyme pocket. Further SAR was explored at the solvent front and near to the H1 pocket and resulted in the discovery of low MW, sub-nanomolar inhibitors of Chk1. | lld:pubmed |
| pubmed-article:17900896 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17900896 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17900896 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17900896 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17900896 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17900896 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17900896 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17900896 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17900896 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17900896 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:HartmanGeorge... | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:RickertKeithK | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:WalshEileen... | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:BuserCarolyn... | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:HamiltonKelly... | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:FraleyMark... | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:AbramsMarc... | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:MunshiSanjeev... | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:Sepp-Lorenzin... | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:YanYouweiY | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:KuoLawrenceL | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:GarbaccioRobe... | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:MaoXianzhiX | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:TasberEdward... | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:TaoWeikangW | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:HuangShaeiS | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:IkutaMariM | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:HardwickJames... | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:BeckStephen... | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:StirdivantSte... | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:DrakasBobB | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:LobellRobR | lld:pubmed |
| pubmed-article:17900896 | pubmed:author | pubmed-author:KreatsoulasCo... | lld:pubmed |
| pubmed-article:17900896 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17900896 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17900896 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:17900896 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17900896 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17900896 | pubmed:pagination | 6280-5 | lld:pubmed |
| pubmed-article:17900896 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
| pubmed-article:17900896 | pubmed:meshHeading | pubmed-meshheading:17900896... | lld:pubmed |
| pubmed-article:17900896 | pubmed:meshHeading | pubmed-meshheading:17900896... | lld:pubmed |
| pubmed-article:17900896 | pubmed:meshHeading | pubmed-meshheading:17900896... | lld:pubmed |
| pubmed-article:17900896 | pubmed:meshHeading | pubmed-meshheading:17900896... | lld:pubmed |
| pubmed-article:17900896 | pubmed:meshHeading | pubmed-meshheading:17900896... | lld:pubmed |
| pubmed-article:17900896 | pubmed:meshHeading | pubmed-meshheading:17900896... | lld:pubmed |
| pubmed-article:17900896 | pubmed:meshHeading | pubmed-meshheading:17900896... | lld:pubmed |
| pubmed-article:17900896 | pubmed:meshHeading | pubmed-meshheading:17900896... | lld:pubmed |
| pubmed-article:17900896 | pubmed:meshHeading | pubmed-meshheading:17900896... | lld:pubmed |
| pubmed-article:17900896 | pubmed:meshHeading | pubmed-meshheading:17900896... | lld:pubmed |
| pubmed-article:17900896 | pubmed:meshHeading | pubmed-meshheading:17900896... | lld:pubmed |
| pubmed-article:17900896 | pubmed:meshHeading | pubmed-meshheading:17900896... | lld:pubmed |
| pubmed-article:17900896 | pubmed:meshHeading | pubmed-meshheading:17900896... | lld:pubmed |
| pubmed-article:17900896 | pubmed:meshHeading | pubmed-meshheading:17900896... | lld:pubmed |
| pubmed-article:17900896 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17900896 | pubmed:articleTitle | Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase. | lld:pubmed |
| pubmed-article:17900896 | pubmed:affiliation | Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. robert_garbaccio@merck.com | lld:pubmed |
| pubmed-article:17900896 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17900896 | lld:chembl |
