| pubmed-article:17895500 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17895500 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:17895500 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:17895500 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:17895500 | lifeskim:mentions | umls-concept:C0043031 | lld:lifeskim |
| pubmed-article:17895500 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:17895500 | lifeskim:mentions | umls-concept:C0002085 | lld:lifeskim |
| pubmed-article:17895500 | lifeskim:mentions | umls-concept:C1332829 | lld:lifeskim |
| pubmed-article:17895500 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17895500 | pubmed:dateCreated | 2008-1-9 | lld:pubmed |
| pubmed-article:17895500 | pubmed:abstractText | This study compared the frequency of variant cytochrome P450 2C9 (CYP2C9) alleles and warfarin S/R concentration ratio in patients who required low-dose (<2.5 mg/day) and average-dose (5+/-0.5 mg/day) warfarin. Patients who achieved a therapeutic international normalized ratio were recruited from the Atlanta Veterans Affairs Medical Center anticoagulation clinic. CYP2C9*2 and *3 alleles were determined by validated Taqman allelic discrimination assays. Warfarin S and R concentrations were determined by chiral capillary electrochromatography with electrospray ionization mass spectrometry. At least 1 variant allele was found in 66.7% and 22.2% of patients in the low-dose and average-dose groups, respectively (P= .001, chi(2)). The warfarin S/R concentration ratio was 0.665 (range, 0.162-3.58) and 0.452 (range, 0.159-2.36) for patients receiving low-dose and average-dose therapy, respectively (P= .097). A warfarin requirement of <2.5 mg/day and an elevated warfarin S/R concentration ratio were each associated with a higher frequency of variant CYP2C9 alleles. | lld:pubmed |
| pubmed-article:17895500 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17895500 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17895500 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17895500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17895500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17895500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17895500 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17895500 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17895500 | pubmed:issn | 1076-0296 | lld:pubmed |
| pubmed-article:17895500 | pubmed:author | pubmed-author:KellyEdward... | lld:pubmed |
| pubmed-article:17895500 | pubmed:author | pubmed-author:ShamsiShahab... | lld:pubmed |
| pubmed-article:17895500 | pubmed:author | pubmed-author:RedmanAndrea... | lld:pubmed |
| pubmed-article:17895500 | pubmed:author | pubmed-author:HonYuen YiYY | lld:pubmed |
| pubmed-article:17895500 | pubmed:author | pubmed-author:HoRodney J... | lld:pubmed |
| pubmed-article:17895500 | pubmed:author | pubmed-author:ZhengJackJ | lld:pubmed |
| pubmed-article:17895500 | pubmed:author | pubmed-author:RitchieDenise... | lld:pubmed |
| pubmed-article:17895500 | pubmed:author | pubmed-author:HuoJingguoJ | lld:pubmed |
| pubmed-article:17895500 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17895500 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:17895500 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17895500 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17895500 | pubmed:pagination | 29-37 | lld:pubmed |
| pubmed-article:17895500 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:17895500 | pubmed:meshHeading | pubmed-meshheading:17895500... | lld:pubmed |
| pubmed-article:17895500 | pubmed:meshHeading | pubmed-meshheading:17895500... | lld:pubmed |
| pubmed-article:17895500 | pubmed:meshHeading | pubmed-meshheading:17895500... | lld:pubmed |
| pubmed-article:17895500 | pubmed:meshHeading | pubmed-meshheading:17895500... | lld:pubmed |
| pubmed-article:17895500 | pubmed:meshHeading | pubmed-meshheading:17895500... | lld:pubmed |
| pubmed-article:17895500 | pubmed:meshHeading | pubmed-meshheading:17895500... | lld:pubmed |
| pubmed-article:17895500 | pubmed:meshHeading | pubmed-meshheading:17895500... | lld:pubmed |
| pubmed-article:17895500 | pubmed:meshHeading | pubmed-meshheading:17895500... | lld:pubmed |
| pubmed-article:17895500 | pubmed:meshHeading | pubmed-meshheading:17895500... | lld:pubmed |
| pubmed-article:17895500 | pubmed:meshHeading | pubmed-meshheading:17895500... | lld:pubmed |
| pubmed-article:17895500 | pubmed:meshHeading | pubmed-meshheading:17895500... | lld:pubmed |
| pubmed-article:17895500 | pubmed:meshHeading | pubmed-meshheading:17895500... | lld:pubmed |
| pubmed-article:17895500 | pubmed:meshHeading | pubmed-meshheading:17895500... | lld:pubmed |
| pubmed-article:17895500 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17895500 | pubmed:articleTitle | Variant CYP2C9 alleles and warfarin concentrations in patients receiving low-dose versus average-dose warfarin therapy. | lld:pubmed |
| pubmed-article:17895500 | pubmed:affiliation | Pharmacy Department, Rockdale Medical Center, Conyers, GA 30012, USA. Andrearredman@yahoo.com | lld:pubmed |
| pubmed-article:17895500 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17895500 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:1559 | entrezgene:pubmed | pubmed-article:17895500 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17895500 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17895500 | lld:entrezgene |
