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pubmed-article:17893600pubmed:abstractTextPneumocystis jiroveci pneumonia may be a life-threatening opportunistic infection in immunosuppressed solid organ transplant recipients. Despite effective treatment with high-dose trimethoprim-sulfamethoxazole and steroids, morbidity is often severe and lethality remains high. New therapeutic approaches are therefore warranted. Caspofungin, a beta-1,3-glucan synthesis inhibitor, has shown activity against the cyst forms of P. jiroveci in experimental animal models. We here report our preliminary clinical experience with caspofungin as an additional drug to the standard trimethoprim-sulfamethoxazole regimen.lld:pubmed
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pubmed-article:17893600pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:17893600pubmed:articleTitleEfficacy of caspofungin addition to trimethoprim-sulfamethoxazole treatment for severe pneumocystis pneumonia in solid organ transplant recipients.lld:pubmed
pubmed-article:17893600pubmed:affiliationUnit of Infectious and Transplant Medicine, Department of Cardiothoracic and Respiratory Sciences, Second University of Naples and AORN V. Monaldi, Naples, Italy. riccardo.utili@ospedalemonaldi.itlld:pubmed
pubmed-article:17893600pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17893600pubmed:publicationTypeCase Reportslld:pubmed
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