| pubmed-article:17888665 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17888665 | lifeskim:mentions | umls-concept:C0026926 | lld:lifeskim |
| pubmed-article:17888665 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:17888665 | lifeskim:mentions | umls-concept:C1710236 | lld:lifeskim |
| pubmed-article:17888665 | lifeskim:mentions | umls-concept:C0258944 | lld:lifeskim |
| pubmed-article:17888665 | lifeskim:mentions | umls-concept:C1871694 | lld:lifeskim |
| pubmed-article:17888665 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:17888665 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:17888665 | pubmed:dateCreated | 2007-10-22 | lld:pubmed |
| pubmed-article:17888665 | pubmed:abstractText | The naphthoquinone 7-methyljuglone (5-hydroxy-7-methyl-1,4-naphthoquinone) has previously been isolated and identified as an active component of root extracts of Euclea natalensis which displays antitubercular activity. Herein, a series of synthetic and plant-derived naphthoquinone derivates of the 7-methyljuglone scaffold have been prepared and evaluated for antibacterial activity against Mycobacterium tuberculosis. Several of these compounds have been shown to operate as subversive substrates with mycothiol disulfide reductase. The absence of a direct correlation between antitubercular activity and subversive substrate efficiency with mycothiol disulfide reductase, might be a consequence of their non-specific reactivity with multiple biological targets (e.g. other disulfide reductases). | lld:pubmed |
| pubmed-article:17888665 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17888665 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17888665 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17888665 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17888665 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17888665 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17888665 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17888665 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17888665 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17888665 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17888665 | pubmed:issn | 1464-3391 | lld:pubmed |
| pubmed-article:17888665 | pubmed:author | pubmed-author:FourieP BPB | lld:pubmed |
| pubmed-article:17888665 | pubmed:author | pubmed-author:HoughtonPeter... | lld:pubmed |
| pubmed-article:17888665 | pubmed:author | pubmed-author:HamiltonChris... | lld:pubmed |
| pubmed-article:17888665 | pubmed:author | pubmed-author:MeyerJ J MJJ | lld:pubmed |
| pubmed-article:17888665 | pubmed:author | pubmed-author:MahapatraAnit... | lld:pubmed |
| pubmed-article:17888665 | pubmed:author | pubmed-author:LallNamritaN | lld:pubmed |
| pubmed-article:17888665 | pubmed:author | pubmed-author:MativandlelaS... | lld:pubmed |
| pubmed-article:17888665 | pubmed:author | pubmed-author:BinnemanBB | lld:pubmed |
| pubmed-article:17888665 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:17888665 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17888665 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17888665 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:17888665 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17888665 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17888665 | pubmed:pagination | 7638-46 | lld:pubmed |
| pubmed-article:17888665 | pubmed:meshHeading | pubmed-meshheading:17888665... | lld:pubmed |
| pubmed-article:17888665 | pubmed:meshHeading | pubmed-meshheading:17888665... | lld:pubmed |
| pubmed-article:17888665 | pubmed:meshHeading | pubmed-meshheading:17888665... | lld:pubmed |
| pubmed-article:17888665 | pubmed:meshHeading | pubmed-meshheading:17888665... | lld:pubmed |
| pubmed-article:17888665 | pubmed:meshHeading | pubmed-meshheading:17888665... | lld:pubmed |
| pubmed-article:17888665 | pubmed:meshHeading | pubmed-meshheading:17888665... | lld:pubmed |
| pubmed-article:17888665 | pubmed:meshHeading | pubmed-meshheading:17888665... | lld:pubmed |
| pubmed-article:17888665 | pubmed:meshHeading | pubmed-meshheading:17888665... | lld:pubmed |
| pubmed-article:17888665 | pubmed:meshHeading | pubmed-meshheading:17888665... | lld:pubmed |
| pubmed-article:17888665 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17888665 | pubmed:articleTitle | Activity of 7-methyljuglone derivatives against Mycobacterium tuberculosis and as subversive substrates for mycothiol disulfide reductase. | lld:pubmed |
| pubmed-article:17888665 | pubmed:affiliation | Department of Botany, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa. | lld:pubmed |
| pubmed-article:17888665 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17888665 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17888665 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17888665 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17888665 | lld:pubmed |
