| pubmed-article:17884990 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17884990 | lifeskim:mentions | umls-concept:C0225698 | lld:lifeskim |
| pubmed-article:17884990 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:17884990 | lifeskim:mentions | umls-concept:C1412058 | lld:lifeskim |
| pubmed-article:17884990 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17884990 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:17884990 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17884990 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17884990 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17884990 | pubmed:dateCreated | 2008-2-18 | lld:pubmed |
| pubmed-article:17884990 | pubmed:abstractText | The mechanisms used by alveolar type I pneumocytes for maintenance of the lipid homeostasis necessary to sustain these large squamous cells are unknown. The processes may involve the ATP-binding cassette transporter A1 (ABCA1), a transport protein shown to be crucial in apolipoprotein A-I (apoA-I)-mediated mobilization of cellular cholesterol and phospholipid. Immunohistochemical data demonstrated the presence of ABCA1 in lung type I and type II cells and in cultured pneumocytes. Type II cells isolated from rat lungs and cultured for 5 days in 10% serum trans-differentiated toward cells with a type I-like phenotype which reacted with the type I cell-specific monoclonal antibody VIIIB2. Upon incubation of the type I-like pneumocytes with agents that up-regulate the ABCA1 gene (9-cis-retinoic acid [9cRA] and 22-hydroxycholesterol [22-OH, 9cRA/22-OH]), ABCA1 protein levels were enhanced to maximum levels after 8 to 16 hours and remained elevated for 24 hours. In the presence of apoA-I and 9cRA/22-OH, efflux of radioactive phospholipid and cholesterol from pneumocytes was stimulated 3- to 20-fold, respectively, over controls. Lipid efflux was inhibited by Probucol. Sucrose density gradient analysis of the media from stimulated cells incubated with apoA-I identified heterogeneous lipid particles that isolated at a density between 1.063 and 1.210 g/ml, with low or high apoA-I content. Thus, pneumocytes with markers for the type I phenotype contained functional ABCA1 protein, released lipid to apoA-I protein, and were capable of producing particles resembling nascent high-density lipoprotein, indicating an important role for ABCA1 in the maintenance of lung lipid homeostasis. | lld:pubmed |
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| pubmed-article:17884990 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17884990 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17884990 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17884990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17884990 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17884990 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17884990 | pubmed:issn | 1535-4989 | lld:pubmed |
| pubmed-article:17884990 | pubmed:author | pubmed-author:BatesSandra... | lld:pubmed |
| pubmed-article:17884990 | pubmed:author | pubmed-author:TaoJian-QinJQ | lld:pubmed |
| pubmed-article:17884990 | pubmed:author | pubmed-author:RothblatGeorg... | lld:pubmed |
| pubmed-article:17884990 | pubmed:author | pubmed-author:CollinsHeidi... | lld:pubmed |
| pubmed-article:17884990 | pubmed:author | pubmed-author:BorokZeaZ | lld:pubmed |
| pubmed-article:17884990 | pubmed:author | pubmed-author:CrandallEdwar... | lld:pubmed |
| pubmed-article:17884990 | pubmed:author | pubmed-author:YuKevin JKJ | lld:pubmed |
| pubmed-article:17884990 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17884990 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:17884990 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17884990 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17884990 | pubmed:pagination | 283-92 | lld:pubmed |
| pubmed-article:17884990 | pubmed:dateRevised | 2010-10-11 | lld:pubmed |
