Linked Life Data

17880284

Source:http://linkedlifedata.com/resource/pubmed/id/17880284

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pubmed-article:17880284pubmed:abstractTextAt least two of the genes predicted to encode type II PI4K (phosphoinositide 4-kinase) in Arabidopsis thaliana (thale cress), namely AtPI4Kgamma4 and AtPI4Kgamma7, encode enzymes with catalytic properties similar to those of members of the PIKK (phosphoinositide kinase-related kinase) family. AtPI4Kgamma4 and AtPI4Kgamma7 undergo autophosphorylation and phosphorylate serine/threonine residues of protein substrates, but have no detectable lipid kinase activity. AtPI4Kgamma4 and AtPI4Kgamma7 are members of a subset of five putative AtPI4Ks that contain N-terminal UBL (ubiquitin-like) domains. In vitro analysis of AtPI4Kgamma4 indicates that it interacts directly with, and phosphorylates, two proteins involved in the ubiquitin-proteasome system, namely UFD1 (ubiquitin fusion degradation 1) and RPN10 (regulatory particle non-ATPase 10). On the basis of the present results, we propose that AtPI4Kgamma4 and AtPI4Kgamma7 should be designated UbDKgamma4 and UbDKgamma7 (ubiquitin-like domain kinases gamma4 and gamma7). These UBL-domain-containing AtPI4Ks correspond to a new PIKK subfamily of protein kinases. Furthermore, UFD1 and RPN10 phosphorylation represents an additional mechanism by which their function can be regulated.lld:pubmed
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pubmed-article:17880284pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:17880284pubmed:articleTitleCharacterization of a new family of protein kinases from Arabidopsis containing phosphoinositide 3/4-kinase and ubiquitin-like domains.lld:pubmed
pubmed-article:17880284pubmed:affiliationDepartment of Plant Biology, North Carolina State University, Raleigh, NC 27695, USA.lld:pubmed
pubmed-article:17880284pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17880284pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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