| pubmed-article:17878335 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17878335 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17878335 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:17878335 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:17878335 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:17878335 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:17878335 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:17878335 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:17878335 | lifeskim:mentions | umls-concept:C1515895 | lld:lifeskim |
| pubmed-article:17878335 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:17878335 | pubmed:dateCreated | 2007-9-19 | lld:pubmed |
| pubmed-article:17878335 | pubmed:abstractText | The frequency of circulating alloreactive human memory T cells correlates with allograft rejection. Memory T cells may be divided into effector memory (T(EM)) and central memory (T(CM)) cell subsets, but their specific roles in allograft rejection are unknown. We report that CD4+ T(EM) (CD45RO+ CCR7- CD62L-) can be adoptively transferred readily into C.B-17 SCID/bg mice and mediate the destruction of human endothelial cells (EC) in vascularized human skin grafts allogeneic to the T cell donor. In contrast, CD4+ T(CM) (CD45RO+ CCR7+ CD62L+) are inefficiently transferred and do not mediate EC injury. In vitro, CD4+ T(EM) secrete more IFN-gamma within 48 h in response to allogeneic ECs than do T(CM). In contrast, T(EM) and T(CM) secrete comparable amounts of IFN-gamma in response to allogeneic monocytes (Mo). In the same cultures, both T(EM) and T(CM) produce IL-2 and proliferate in response to IFN-gamma-treated allogeneic human EC or Mo, but T(CM) respond more vigorously in both assays. Blockade of LFA-3 strongly inhibits both IL-2 and IFN-gamma secretion by CD4+ T(EM) cultured with allogeneic EC but only minimally inhibits responses to allogeneic Mo. Blockade of CD80 and CD86 strongly inhibits IL-2 but not IFN-gamma production by in response to allogeneic EC or Mo. Transduction of EC to express B7-2 enhances allogeneic T(EM) production of IL-2 but not IFN-gamma. We conclude that human CD4+ T(EM) directly recognize and respond to allogeneic EC in vitro by secreting IFN-gamma and that this response depends on CD2 but not CD28. Consistent with EC activation of effector functions, human CD4+ T(EM) can mediate allogeneic EC injury in vivo. | lld:pubmed |
| pubmed-article:17878335 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17878335 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17878335 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:17878335 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17878335 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17878335 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17878335 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17878335 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17878335 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17878335 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:17878335 | pubmed:author | pubmed-author:PoberJordan... | lld:pubmed |
| pubmed-article:17878335 | pubmed:author | pubmed-author:ShiaoStephen... | lld:pubmed |
| pubmed-article:17878335 | pubmed:author | pubmed-author:McNiffJennife... | lld:pubmed |
| pubmed-article:17878335 | pubmed:author | pubmed-author:Kirkiles-Smit... | lld:pubmed |
| pubmed-article:17878335 | pubmed:author | pubmed-author:ShepherdBenja... | lld:pubmed |
| pubmed-article:17878335 | pubmed:author | pubmed-author:CarrEdward... | lld:pubmed |
| pubmed-article:17878335 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17878335 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17878335 | pubmed:volume | 179 | lld:pubmed |
| pubmed-article:17878335 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17878335 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17878335 | pubmed:pagination | 4397-404 | lld:pubmed |
| pubmed-article:17878335 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:17878335 | pubmed:meshHeading | pubmed-meshheading:17878335... | lld:pubmed |
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| pubmed-article:17878335 | pubmed:meshHeading | pubmed-meshheading:17878335... | lld:pubmed |
| pubmed-article:17878335 | pubmed:meshHeading | pubmed-meshheading:17878335... | lld:pubmed |
| pubmed-article:17878335 | pubmed:meshHeading | pubmed-meshheading:17878335... | lld:pubmed |
| pubmed-article:17878335 | pubmed:meshHeading | pubmed-meshheading:17878335... | lld:pubmed |
| pubmed-article:17878335 | pubmed:meshHeading | pubmed-meshheading:17878335... | lld:pubmed |
| pubmed-article:17878335 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17878335 | pubmed:articleTitle | Human effector memory CD4+ T cells directly recognize allogeneic endothelial cells in vitro and in vivo. | lld:pubmed |
| pubmed-article:17878335 | pubmed:affiliation | Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. | lld:pubmed |
| pubmed-article:17878335 | pubmed:publicationType | Journal Article | lld:pubmed |
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