| pubmed-article:17878156 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17878156 | lifeskim:mentions | umls-concept:C0023516 | lld:lifeskim |
| pubmed-article:17878156 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
| pubmed-article:17878156 | lifeskim:mentions | umls-concept:C0033607 | lld:lifeskim |
| pubmed-article:17878156 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17878156 | lifeskim:mentions | umls-concept:C0054874 | lld:lifeskim |
| pubmed-article:17878156 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17878156 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17878156 | pubmed:issue | 46 | lld:pubmed |
| pubmed-article:17878156 | pubmed:dateCreated | 2007-11-12 | lld:pubmed |
| pubmed-article:17878156 | pubmed:abstractText | We have demonstrated that bronchoalveolar lavage fluid from chronic obstructive pulmonary disease patients contains higher levels of interferon-gamma compared with controls. Interferon-gamma is a potent inducer of various cathepsins and matrix metalloproteases. Therefore, we postulated that interferon-gamma could induce protease expression by macrophages in acute and chronic lung disease. Chronic obstructive pulmonary disease patients had greater levels of cathepsin S and matrix metalloprotease-12 in their bronchoalveolar lavage fluid. Macrophages incubated with chronic obstructive pulmonary disease bronchoalveolar lavage fluid exhibited increased expression of cathepsin S and matrix metalloprotease-12, which was inhibited by the addition of interferon-gamma-neutralizing immunoglobulin. Human secretory leukocyte protease inhibitor is an 11.7-kDa cationic non-glycosylated antiprotease synthesized and secreted by cells at the site of inflammation. We have demonstrated that secretory leukocyte protease inhibitor can inhibit interferon-gamma-induced cathepsin S production by macrophages. Pretreatment of macrophages with secretory leukocyte protease inhibitor inhibited interferon-gamma-induced inhibitor kappaB beta degradation and activation of nuclear factor kappaB. Secretory leukocyte protease inhibitor may prove to be therapeutically important as a potential inhibitor of protease expression in chronic obstructive pulmonary disease. | lld:pubmed |
| pubmed-article:17878156 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17878156 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17878156 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17878156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17878156 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17878156 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17878156 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:17878156 | pubmed:author | pubmed-author:O'MahonyMicha... | lld:pubmed |
| pubmed-article:17878156 | pubmed:author | pubmed-author:TaggartCliffo... | lld:pubmed |
| pubmed-article:17878156 | pubmed:author | pubmed-author:GreeneCatheri... | lld:pubmed |
| pubmed-article:17878156 | pubmed:author | pubmed-author:McElvaneyNoel... | lld:pubmed |
| pubmed-article:17878156 | pubmed:author | pubmed-author:O'NeillShane... | lld:pubmed |
| pubmed-article:17878156 | pubmed:author | pubmed-author:GeraghtyPatri... | lld:pubmed |
| pubmed-article:17878156 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17878156 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:17878156 | pubmed:volume | 282 | lld:pubmed |
| pubmed-article:17878156 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17878156 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17878156 | pubmed:pagination | 33389-95 | lld:pubmed |
| pubmed-article:17878156 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:17878156 | pubmed:meshHeading | pubmed-meshheading:17878156... | lld:pubmed |
| pubmed-article:17878156 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17878156 | pubmed:articleTitle | Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression. | lld:pubmed |
| pubmed-article:17878156 | pubmed:affiliation | Pulmonary Research Division, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin 9, Ireland. | lld:pubmed |
| pubmed-article:17878156 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17878156 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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