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pubmed-article:17875776pubmed:abstractTextRecent studies showed that Fas ligand (FasL) induced apoptosis in tumor cells and suppressed the immune response in several types of tumors. However, the toxicity of FasL limited further administration. This study delivered FasL in prostate cancer cells using an improved prostate-restricted replicative adenovirus (PRRA), thereby improving the antitumor effect while decreasing systemic toxicity.lld:pubmed
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pubmed-article:17875776pubmed:articleTitleFas ligand delivery by a prostate-restricted replicative adenovirus enhances safety and antitumor efficacy.lld:pubmed
pubmed-article:17875776pubmed:affiliationDepartment of Urology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA..lld:pubmed
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