| pubmed-article:17870214 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17870214 | lifeskim:mentions | umls-concept:C0002331 | lld:lifeskim |
| pubmed-article:17870214 | lifeskim:mentions | umls-concept:C0010825 | lld:lifeskim |
| pubmed-article:17870214 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:17870214 | lifeskim:mentions | umls-concept:C0035142 | lld:lifeskim |
| pubmed-article:17870214 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:17870214 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:17870214 | lifeskim:mentions | umls-concept:C0597177 | lld:lifeskim |
| pubmed-article:17870214 | lifeskim:mentions | umls-concept:C1709630 | lld:lifeskim |
| pubmed-article:17870214 | pubmed:issue | 42 | lld:pubmed |
| pubmed-article:17870214 | pubmed:dateCreated | 2007-10-2 | lld:pubmed |
| pubmed-article:17870214 | pubmed:abstractText | We used a replication-incompetent, single-cycle, alphavirus replicon vector system to produce virus-like replicon particles (VRP) expressing the extracellular domain of human cytomegalovirus (CMV) glycoprotein B or a pp65/IE1 fusion protein. Efficient production methods were scaled to produce pilot lots and clinical lots of each alphavirus replicon vaccine component. The vaccine induced high-titered antibody responses in mice and rabbits, as measured by ELISA and CMV neutralization assays, and robust T-cell responses in mice, as measured by IFN-gamma ELISPOT assay. A toxicity study in rabbits showed no adverse effects in any toxicology parameter. These studies support clinical testing of this novel CMV alphavirus replicon vaccine in humans. | lld:pubmed |
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| pubmed-article:17870214 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17870214 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17870214 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17870214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17870214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17870214 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17870214 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17870214 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:17870214 | pubmed:author | pubmed-author:GrahamAndrewA | lld:pubmed |
| pubmed-article:17870214 | pubmed:author | pubmed-author:MorrisJohnJ | lld:pubmed |
| pubmed-article:17870214 | pubmed:author | pubmed-author:EschRobert... | lld:pubmed |
| pubmed-article:17870214 | pubmed:author | pubmed-author:ReapElizabeth... | lld:pubmed |
| pubmed-article:17870214 | pubmed:author | pubmed-author:MaughanMauree... | lld:pubmed |
| pubmed-article:17870214 | pubmed:author | pubmed-author:DrygaSergey... | lld:pubmed |
| pubmed-article:17870214 | pubmed:author | pubmed-author:ChulayJeffrey... | lld:pubmed |
| pubmed-article:17870214 | pubmed:author | pubmed-author:OlmstedRobert... | lld:pubmed |
| pubmed-article:17870214 | pubmed:author | pubmed-author:TalaricoToddT | lld:pubmed |
| pubmed-article:17870214 | pubmed:author | pubmed-author:NegriSarahS | lld:pubmed |
| pubmed-article:17870214 | pubmed:author | pubmed-author:BurnettBruceB | lld:pubmed |
| pubmed-article:17870214 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17870214 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:17870214 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:17870214 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17870214 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17870214 | pubmed:pagination | 7441-9 | lld:pubmed |
| pubmed-article:17870214 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17870214 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17870214 | pubmed:articleTitle | Development and preclinical evaluation of an alphavirus replicon particle vaccine for cytomegalovirus. | lld:pubmed |
| pubmed-article:17870214 | pubmed:affiliation | AlphaVax Inc., Research Triangle Park, NC 27709, USA. | lld:pubmed |
| pubmed-article:17870214 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17870214 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17870214 | lld:pubmed |
