| pubmed-article:17869525 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17869525 | lifeskim:mentions | umls-concept:C0001044 | lld:lifeskim |
| pubmed-article:17869525 | lifeskim:mentions | umls-concept:C0030020 | lld:lifeskim |
| pubmed-article:17869525 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:17869525 | pubmed:dateCreated | 2007-10-22 | lld:pubmed |
| pubmed-article:17869525 | pubmed:abstractText | New bis-pyridinium oxime reactivators 6 with CH(2)O(CH(2))(2)OCH(2) and CH(2)O(CH(2))(4)OCH(2) linkers between the two pyridinium rings were designed and synthesized. In the in vitro test of their potency to reactivate AChE inhibited by organophosphorus agents at 5 x 10(-3)M concentration, the reactivation ability of 1,2-dimethoxy-ethylene-bis-N,N'-4-pyridiumaldoxime dichloride (6a) was 63% for housefly (HF) AChE inhibited by diisopropyl fluorophosphates (DFP), 51% for bovine red blood cell (RBC) AChE inhibited by DFP, 67% for HF-AChE inhibited by paraoxon, and 81% for RBC-AChE inhibited by paraoxon. Except in the case of DFP-inhibited HF AChE test of 2-PAM, the activities of 6a are much higher than the activities of 2-PAM and HI-6 which are AChE reactivators currently in use. | lld:pubmed |
| pubmed-article:17869525 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17869525 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17869525 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17869525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17869525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17869525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17869525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17869525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17869525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17869525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17869525 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17869525 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17869525 | pubmed:issn | 1464-3391 | lld:pubmed |
| pubmed-article:17869525 | pubmed:author | pubmed-author:JungYoung-Sik... | lld:pubmed |
| pubmed-article:17869525 | pubmed:author | pubmed-author:OhKyung-AeKA | lld:pubmed |
| pubmed-article:17869525 | pubmed:author | pubmed-author:YangGarp... | lld:pubmed |
| pubmed-article:17869525 | pubmed:author | pubmed-author:ParkNo-JoongN... | lld:pubmed |
| pubmed-article:17869525 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17869525 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17869525 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:17869525 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17869525 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17869525 | pubmed:pagination | 7704-10 | lld:pubmed |
| pubmed-article:17869525 | pubmed:meshHeading | pubmed-meshheading:17869525... | lld:pubmed |
| pubmed-article:17869525 | pubmed:meshHeading | pubmed-meshheading:17869525... | lld:pubmed |
| pubmed-article:17869525 | pubmed:meshHeading | pubmed-meshheading:17869525... | lld:pubmed |
| pubmed-article:17869525 | pubmed:meshHeading | pubmed-meshheading:17869525... | lld:pubmed |
| pubmed-article:17869525 | pubmed:meshHeading | pubmed-meshheading:17869525... | lld:pubmed |
| pubmed-article:17869525 | pubmed:meshHeading | pubmed-meshheading:17869525... | lld:pubmed |
| pubmed-article:17869525 | pubmed:meshHeading | pubmed-meshheading:17869525... | lld:pubmed |
| pubmed-article:17869525 | pubmed:meshHeading | pubmed-meshheading:17869525... | lld:pubmed |
| pubmed-article:17869525 | pubmed:meshHeading | pubmed-meshheading:17869525... | lld:pubmed |
| pubmed-article:17869525 | pubmed:meshHeading | pubmed-meshheading:17869525... | lld:pubmed |
| pubmed-article:17869525 | pubmed:meshHeading | pubmed-meshheading:17869525... | lld:pubmed |
| pubmed-article:17869525 | pubmed:meshHeading | pubmed-meshheading:17869525... | lld:pubmed |
| pubmed-article:17869525 | pubmed:meshHeading | pubmed-meshheading:17869525... | lld:pubmed |
| pubmed-article:17869525 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17869525 | pubmed:articleTitle | New oxime reactivators connected with CH2O(CH2)nOCH2 linker and their reactivation potency for organophosphorus agents-inhibited acetylcholinesterase. | lld:pubmed |
| pubmed-article:17869525 | pubmed:affiliation | Drug Discovery Division, Korea Research Institute of Chemical Technology, PO Box 107, Yuseong, Daejeon 305-600, Republic of Korea. | lld:pubmed |
| pubmed-article:17869525 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17869525 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17869525 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17869525 | lld:pubmed |
