Linked Life Data

17854949

Source:http://linkedlifedata.com/resource/pubmed/id/17854949

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pubmed-article:17854949pubmed:abstractTextTo identify the tumor suppressor genes (TSG) associated with non-small cell lung cancers (NSCLC), we performed the loss of heterozygosity (LOH) analysis in NSCLC samples from 66 patients. We focused on the novel hot spot region on 15q14-24 with eight polymorphic microsatellite markers. Frequent allelic loss was detected in 33 of 48 informative cases (69%) at D15S984 on 15q23. We defined the fine map on the region and identified the SIN3A gene as a candidate TSG. The SIN3A gene product is a component of the histone deacetylase (HDAC) complex and plays essential roles in early embryonic development and the proliferation and survival of a variety of cells through the repression of diverse signaling pathways. Our expression analysis revealed more frequent down-regulation of the SIN3A mRNA in 19 of 31 cases (61%) of NSCLCs in comparison to those of other flanking genes (16-42%), albeit the correlation of the decreased expression with the LOH did not attain statistic significance. These results suggest that the attenuated function of SIN3A due to a decreased level of expression may result in epigenetic de-regulation of growth-related genes through histone acetylation, which leads to the tumorigenesis of lung cancer cells. To our knowledge, this is the first evidence of the down-regulation of the SIN3A gene in human cancer.lld:pubmed
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pubmed-article:17854949pubmed:articleTitleDecreased expression of the SIN3A gene, a candidate tumor suppressor located at the prevalent allelic loss region 15q23 in non-small cell lung cancer.lld:pubmed
pubmed-article:17854949pubmed:affiliationDepartment of Surgical Oncology and Thoracic Surgery, Okayama University, Shikata-cho 2-5-1, Okayama 700-8558, Japan.lld:pubmed
pubmed-article:17854949pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17854949pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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