| pubmed-article:17850257 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17850257 | lifeskim:mentions | umls-concept:C1687052 | lld:lifeskim |
| pubmed-article:17850257 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:17850257 | lifeskim:mentions | umls-concept:C1158478 | lld:lifeskim |
| pubmed-article:17850257 | lifeskim:mentions | umls-concept:C1705422 | lld:lifeskim |
| pubmed-article:17850257 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:17850257 | lifeskim:mentions | umls-concept:C0075739 | lld:lifeskim |
| pubmed-article:17850257 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17850257 | pubmed:dateCreated | 2007-9-27 | lld:pubmed |
| pubmed-article:17850257 | pubmed:abstractText | Agrobacterium tumefaciens-mediated transformation (ATMT) has become a prevalent tool for functional genomics of fungi, but our understanding of T-DNA integration into the fungal genome remains limited relative to that in plants. Using a model plant-pathogenic fungus, Magnaporthe oryzae, here we report the most comprehensive analysis of T-DNA integration events in fungi and the development of an informatics infrastructure, termed a T-DNA analysis platform (TAP). We identified a total of 1110 T-DNA-tagged locations (TTLs) and processed the resulting data via TAP. Analysis of the TTLs showed that T-DNA integration was biased among chromosomes and preferred the promoter region of genes. In addition, irregular patterns of T-DNA integration, such as chromosomal rearrangement and readthrough of plasmid vectors, were also observed, showing that T-DNA integration patterns into the fungal genome are as diverse as those of their plant counterparts. However, overall the observed junction structures between T-DNA borders and flanking genomic DNA sequences revealed that T-DNA integration into the fungal genome was more canonical than those observed in plants. Our results support the potential of ATMT as a tool for functional genomics of fungi and show that the TAP is an effective informatics platform for handling data from large-scale insertional mutagenesis. | lld:pubmed |
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| pubmed-article:17850257 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17850257 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17850257 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17850257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17850257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17850257 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17850257 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17850257 | pubmed:issn | 0950-382X | lld:pubmed |
| pubmed-article:17850257 | pubmed:author | pubmed-author:LeeYong-HwanY... | lld:pubmed |
| pubmed-article:17850257 | pubmed:author | pubmed-author:ParkSook-Youn... | lld:pubmed |
| pubmed-article:17850257 | pubmed:author | pubmed-author:KangSeogchanS | lld:pubmed |
| pubmed-article:17850257 | pubmed:author | pubmed-author:ParkJongsunJ | lld:pubmed |
| pubmed-article:17850257 | pubmed:author | pubmed-author:KimHyojeongH | lld:pubmed |
| pubmed-article:17850257 | pubmed:author | pubmed-author:ChoiJaehyukJ | lld:pubmed |
| pubmed-article:17850257 | pubmed:author | pubmed-author:KimSoonokS | lld:pubmed |
| pubmed-article:17850257 | pubmed:author | pubmed-author:RhoHee-SoolHS | lld:pubmed |
| pubmed-article:17850257 | pubmed:author | pubmed-author:HanSeong-Sook... | lld:pubmed |
| pubmed-article:17850257 | pubmed:author | pubmed-author:JeonJunhyunJ | lld:pubmed |
| pubmed-article:17850257 | pubmed:author | pubmed-author:ChiMyoung-Hwa... | lld:pubmed |
| pubmed-article:17850257 | pubmed:author | pubmed-author:GohJaedukJ | lld:pubmed |
| pubmed-article:17850257 | pubmed:author | pubmed-author:KimByeong... | lld:pubmed |
| pubmed-article:17850257 | pubmed:author | pubmed-author:JungKyongyong... | lld:pubmed |
| pubmed-article:17850257 | pubmed:author | pubmed-author:ParkJaejinJ | lld:pubmed |
| pubmed-article:17850257 | pubmed:author | pubmed-author:YooSung-YongS... | lld:pubmed |
| pubmed-article:17850257 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17850257 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:17850257 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17850257 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17850257 | pubmed:pagination | 371-82 | lld:pubmed |
| pubmed-article:17850257 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:17850257 | pubmed:meshHeading | pubmed-meshheading:17850257... | lld:pubmed |
| pubmed-article:17850257 | pubmed:meshHeading | pubmed-meshheading:17850257... | lld:pubmed |
| pubmed-article:17850257 | pubmed:meshHeading | pubmed-meshheading:17850257... | lld:pubmed |
| pubmed-article:17850257 | pubmed:meshHeading | pubmed-meshheading:17850257... | lld:pubmed |
| pubmed-article:17850257 | pubmed:meshHeading | pubmed-meshheading:17850257... | lld:pubmed |
