pubmed-article:17848618 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C0086282 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C0026764 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C0215848 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C0965644 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C1333897 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C1704838 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C1426234 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
pubmed-article:17848618 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
pubmed-article:17848618 | pubmed:issue | 13 | lld:pubmed |
pubmed-article:17848618 | pubmed:dateCreated | 2007-12-6 | lld:pubmed |
pubmed-article:17848618 | pubmed:abstractText | Angiogenesis has a critical role in the pathophysiology of multiple myeloma (MM); however, the molecular mechanisms underlying this process are not completely elucidated. The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) has been recently implicated in solid tumors as a repressor of angiogenesis. In this study, we found that ING4 expression in MM cells was correlated with the expression of the proangiogenic molecules interleukin-8 (IL-8) and osteopontin (OPN). Moreover, we demonstrate that ING4 suppression in MM cells up-regulated IL-8 and OPN, increasing the hypoxia inducible factor-1alpha (HIF-1alpha) activity and its target gene NIP-3 expression in hypoxic condition. In turn, we show that the inhibition of HIF-1alpha by siRNA suppressed IL-8 and OPN production by MM cells under hypoxia. A direct interaction between ING4 and the HIF prolyl hydroxylase 2 (HPH-2) was also demonstrated. Finally, we show that ING4 suppression in MM cells significantly increased vessel formation in vitro, blunted by blocking IL-8 or OPN. These in vitro observations were confirmed in vivo by finding that MM patients with high IL-8 production and microvascular density (MVD) have significantly lower ING4 levels compared with those with low IL-8 and MVD. Our data indicate that ING4 exerts an inhibitory effect on the production of proangiogenic molecules and consequently on MM-induced angiogenesis. | lld:pubmed |
pubmed-article:17848618 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17848618 | pubmed:language | eng | lld:pubmed |
pubmed-article:17848618 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17848618 | pubmed:citationSubset | AIM | lld:pubmed |
pubmed-article:17848618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:17848618 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17848618 | pubmed:month | Dec | lld:pubmed |
pubmed-article:17848618 | pubmed:issn | 0006-4971 | lld:pubmed |
pubmed-article:17848618 | pubmed:author | pubmed-author:MirandaClaudi... | lld:pubmed |
pubmed-article:17848618 | pubmed:author | pubmed-author:GrecoAngelaA | lld:pubmed |
pubmed-article:17848618 | pubmed:author | pubmed-author:LadettoMarcoM | lld:pubmed |
pubmed-article:17848618 | pubmed:author | pubmed-author:MorandiFrance... | lld:pubmed |
pubmed-article:17848618 | pubmed:author | pubmed-author:DonofrioGaeta... | lld:pubmed |
pubmed-article:17848618 | pubmed:author | pubmed-author:RizzoliVittor... | lld:pubmed |
pubmed-article:17848618 | pubmed:author | pubmed-author:BonatiAntonio... | lld:pubmed |
pubmed-article:17848618 | pubmed:author | pubmed-author:LunghiPaoloP | lld:pubmed |
pubmed-article:17848618 | pubmed:author | pubmed-author:NeriTauro... | lld:pubmed |
pubmed-article:17848618 | pubmed:author | pubmed-author:NeriAntoninoA | lld:pubmed |
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pubmed-article:17848618 | pubmed:author | pubmed-author:CollaSimonaS | lld:pubmed |
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pubmed-article:17848618 | pubmed:author | pubmed-author:BonominiSabri... | lld:pubmed |
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pubmed-article:17848618 | pubmed:author | pubmed-author:TagliaferriSa... | lld:pubmed |
pubmed-article:17848618 | pubmed:author | pubmed-author:MazzeraLauraL | lld:pubmed |
pubmed-article:17848618 | pubmed:author | pubmed-author:MangoniMarcel... | lld:pubmed |
pubmed-article:17848618 | pubmed:author | pubmed-author:FerrariLucaL | lld:pubmed |
pubmed-article:17848618 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:17848618 | pubmed:day | 15 | lld:pubmed |
pubmed-article:17848618 | pubmed:volume | 110 | lld:pubmed |
pubmed-article:17848618 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17848618 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17848618 | pubmed:pagination | 4464-75 | lld:pubmed |
pubmed-article:17848618 | pubmed:dateRevised | 2008-9-30 | lld:pubmed |
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pubmed-article:17848618 | pubmed:year | 2007 | lld:pubmed |
pubmed-article:17848618 | pubmed:articleTitle | The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angiogenesis. | lld:pubmed |
pubmed-article:17848618 | pubmed:affiliation | Hematology and Bone Marrow Transplantation Center, University of Parma, Parma, Italy. | lld:pubmed |
pubmed-article:17848618 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:17848618 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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