| pubmed-article:17848519 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17848519 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17848519 | lifeskim:mentions | umls-concept:C0005953 | lld:lifeskim |
| pubmed-article:17848519 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:17848519 | lifeskim:mentions | umls-concept:C0029453 | lld:lifeskim |
| pubmed-article:17848519 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:17848519 | lifeskim:mentions | umls-concept:C0242606 | lld:lifeskim |
| pubmed-article:17848519 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:17848519 | lifeskim:mentions | umls-concept:C1326120 | lld:lifeskim |
| pubmed-article:17848519 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:17848519 | pubmed:issue | 38 | lld:pubmed |
| pubmed-article:17848519 | pubmed:dateCreated | 2007-9-19 | lld:pubmed |
| pubmed-article:17848519 | pubmed:abstractText | Increased production of tumor necrosis factor alpha (TNF) in the bone marrow (BM) in response to both oxidative stress and T cell activation contributes to the bone loss induced by estrogen deficiency, but it is presently unknown whether oxidative stress causes bone loss through T cells. Here we show that ovariectomy causes an accumulation in the BM of reactive oxygen species, which leads to increased production of TNF by activated T cells through up-regulation of the costimulatory molecule CD80 on dendritic cells. Accordingly, bone loss is prevented by treatment of ovariectomized mice with either antioxidants or CTLA4-Ig, an inhibitor of the CD80/CD28 pathway. In summary, reactive oxygen species accumulation in the BM is an upstream consequence of ovariectomy that leads to bone loss by activating T cells through enhanced activity of BM dendritic cells, and these findings suggest that the CD80/CD28 pathway may represent a therapeutic target for postmenopausal bone loss. | lld:pubmed |
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| pubmed-article:17848519 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17848519 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17848519 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17848519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17848519 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17848519 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17848519 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:17848519 | pubmed:author | pubmed-author:TellGianlucaG | lld:pubmed |
| pubmed-article:17848519 | pubmed:author | pubmed-author:TerauchiMasak... | lld:pubmed |
| pubmed-article:17848519 | pubmed:author | pubmed-author:JonesDean PDP | lld:pubmed |
| pubmed-article:17848519 | pubmed:author | pubmed-author:Robbie-RyanMi... | lld:pubmed |
| pubmed-article:17848519 | pubmed:author | pubmed-author:RomanelloMile... | lld:pubmed |
| pubmed-article:17848519 | pubmed:author | pubmed-author:GrassiFrances... | lld:pubmed |
| pubmed-article:17848519 | pubmed:author | pubmed-author:WeitzmannM... | lld:pubmed |
| pubmed-article:17848519 | pubmed:author | pubmed-author:PacificiRober... | lld:pubmed |
| pubmed-article:17848519 | pubmed:author | pubmed-author:GaoYuhaoY | lld:pubmed |
| pubmed-article:17848519 | pubmed:author | pubmed-author:YangXiaoyingX | lld:pubmed |
| pubmed-article:17848519 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17848519 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:17848519 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:17848519 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17848519 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17848519 | pubmed:pagination | 15087-92 | lld:pubmed |
| pubmed-article:17848519 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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