| pubmed-article:17828742 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17828742 | lifeskim:mentions | umls-concept:C0008377 | lld:lifeskim |
| pubmed-article:17828742 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17828742 | lifeskim:mentions | umls-concept:C0000854 | lld:lifeskim |
| pubmed-article:17828742 | lifeskim:mentions | umls-concept:C1142985 | lld:lifeskim |
| pubmed-article:17828742 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:17828742 | lifeskim:mentions | umls-concept:C0743223 | lld:lifeskim |
| pubmed-article:17828742 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:17828742 | pubmed:dateCreated | 2007-11-1 | lld:pubmed |
| pubmed-article:17828742 | pubmed:abstractText | The lipid lowering agent ezetimibe (EZ) and its intestinally formed glucuronide (GLUC) were shown to be substrates of the efflux transporters P-glycoprotein (P-gp) and the multidrug resistance associated protein 2 (MRP2) which markedly influences the disposition and efficacy of EZ in man. This study aims to elucidate the unique meaning of P-gp in the pharmacokinetics of EZ in mice. In brief, serum concentrations, organ distribution and elimination of EZ were determined in 10 male wild-type and mdr1a/b (-/-) mice after oral treatment with EZ (10 mg/kg, 10 days). EZ and GLUC were quantified in serum, urine, feces and various tissues using a validated LC-MS/MS method. Compared to wild-type mice, mdr1a/b knockout was associated with significantly increased serum concentrations of GLUC (5.58 +/- 2.07 versus 2.09 +/- 0.83 ng/ml, p < 0.001) but not of EZ (0.92 +/- 0.73 versus 0.55 +/- 0.40 ng/ml, n.s.). Consequently, urinary excretion of GLUC was about three-fold increased (9.96 +/- 0.27 versus 3.10 +/- 1.37 microg/day, p = 0.049) whereas renal clearance and the amount excreted via feces remained unchanged. Both EZ and GLUC were not over-proportionally distributed into investigated organs. P-glycoprotein primary influences the oral absorption of ezetimibe in mice. Distribution, renal and fecal excretion of the drug seems not to be markedly affected by P-glycoprotein. | lld:pubmed |
| pubmed-article:17828742 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17828742 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17828742 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17828742 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17828742 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17828742 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17828742 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17828742 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17828742 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17828742 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17828742 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17828742 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17828742 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17828742 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17828742 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17828742 | pubmed:issn | 0022-3549 | lld:pubmed |
| pubmed-article:17828742 | pubmed:author | pubmed-author:SiegmundWerne... | lld:pubmed |
| pubmed-article:17828742 | pubmed:author | pubmed-author:OswaldStefanS | lld:pubmed |
| pubmed-article:17828742 | pubmed:author | pubmed-author:KollChristian... | lld:pubmed |
| pubmed-article:17828742 | pubmed:copyrightInfo | (c) 2007 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:17828742 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17828742 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:17828742 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17828742 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17828742 | pubmed:pagination | 3478-84 | lld:pubmed |
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| pubmed-article:17828742 | pubmed:meshHeading | pubmed-meshheading:17828742... | lld:pubmed |
| pubmed-article:17828742 | pubmed:meshHeading | pubmed-meshheading:17828742... | lld:pubmed |
| pubmed-article:17828742 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17828742 | pubmed:articleTitle | Disposition of the cholesterol absorption inhibitor ezetimibe in mdr1a/b (-/-) mice. | lld:pubmed |
| pubmed-article:17828742 | pubmed:affiliation | Department of Clinical Pharmacology, University of Greifswald, Friedrich-Loeffler-Strasse 23d, Greifswald, Germany. stefan.oswald@uni-greifswald.de | lld:pubmed |
| pubmed-article:17828742 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17828742 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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