| pubmed-article:17825820 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17825820 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:17825820 | lifeskim:mentions | umls-concept:C0001473 | lld:lifeskim |
| pubmed-article:17825820 | lifeskim:mentions | umls-concept:C0387583 | lld:lifeskim |
| pubmed-article:17825820 | lifeskim:mentions | umls-concept:C0001884 | lld:lifeskim |
| pubmed-article:17825820 | lifeskim:mentions | umls-concept:C1621574 | lld:lifeskim |
| pubmed-article:17825820 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17825820 | lifeskim:mentions | umls-concept:C0597484 | lld:lifeskim |
| pubmed-article:17825820 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:17825820 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:17825820 | lifeskim:mentions | umls-concept:C1709843 | lld:lifeskim |
| pubmed-article:17825820 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:17825820 | pubmed:dateCreated | 2007-9-24 | lld:pubmed |
| pubmed-article:17825820 | pubmed:abstractText | In the mouse macrophage-like cell line RAW 264, vacuolar-type (H(+))-ATPase (V-ATPase) inhibitors, bafilomycin A(1) and concanamycin A, increased the level of cyclooxygenase (COX)-2 protein and its mRNA. The V-ATPase inhibitor-induced expression of COX-2 was suppressed by inhibitors of c-jun N-terminal kinase (JNK) and nuclear factor-kappaB, and by inhibitors of Na(+)/H(+) exchangers (NHEs). The bafilomycin A(1)-induced activation of JNK but not degradation of IkappaB-alpha was suppressed by NHE inhibitors and by an inhibitor of Na(+)/Ca(2+) exchanger SN-6. These results suggested that V-ATPase inhibitors induce the expression of COX-2 via NHE-dependent and -independent pathways. | lld:pubmed |
| pubmed-article:17825820 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17825820 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17825820 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17825820 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17825820 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17825820 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17825820 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17825820 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17825820 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:17825820 | pubmed:author | pubmed-author:OhuchiKazuoK | lld:pubmed |
| pubmed-article:17825820 | pubmed:author | pubmed-author:IshiharaKenji... | lld:pubmed |
| pubmed-article:17825820 | pubmed:author | pubmed-author:HirasawaNoriy... | lld:pubmed |
| pubmed-article:17825820 | pubmed:author | pubmed-author:BanHyun... | lld:pubmed |
| pubmed-article:17825820 | pubmed:author | pubmed-author:HongJangjaJ | lld:pubmed |
| pubmed-article:17825820 | pubmed:author | pubmed-author:KamachiFumita... | lld:pubmed |
| pubmed-article:17825820 | pubmed:author | pubmed-author:YanaiMaikoM | lld:pubmed |
| pubmed-article:17825820 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17825820 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:17825820 | pubmed:volume | 581 | lld:pubmed |
| pubmed-article:17825820 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17825820 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17825820 | pubmed:pagination | 4633-8 | lld:pubmed |
| pubmed-article:17825820 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:17825820 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17825820 | pubmed:articleTitle | Involvement of Na+/H+ exchangers in induction of cyclooxygenase-2 by vacuolar-type (H+)-ATPase inhibitors in RAW 264 cells. | lld:pubmed |
| pubmed-article:17825820 | pubmed:affiliation | Laboratory of Pathophysiological Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan. | lld:pubmed |
| pubmed-article:17825820 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:19225 | entrezgene:pubmed | pubmed-article:17825820 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17825820 | lld:entrezgene |
