| pubmed-article:17803058 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17803058 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:17803058 | lifeskim:mentions | umls-concept:C0070122 | lld:lifeskim |
| pubmed-article:17803058 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:17803058 | lifeskim:mentions | umls-concept:C0039789 | lld:lifeskim |
| pubmed-article:17803058 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:17803058 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:17803058 | lifeskim:mentions | umls-concept:C0599748 | lld:lifeskim |
| pubmed-article:17803058 | lifeskim:mentions | umls-concept:C0201734 | lld:lifeskim |
| pubmed-article:17803058 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:17803058 | lifeskim:mentions | umls-concept:C0008565 | lld:lifeskim |
| pubmed-article:17803058 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:17803058 | pubmed:dateCreated | 2007-9-6 | lld:pubmed |
| pubmed-article:17803058 | pubmed:abstractText | A rapid and validated liquid chromatography coupled to tandem mass spectrometric method (LC-MS-MS) has been developed and applied to pharmacokinetic and bioequivalence studies in 24 healthy male Korean volunteers. The procedure involves a liquid-liquid extraction of paroxetine (CAS 61869-08-7) and fluoxetine (internal standard, CAS 54910-89-3) with ether/methyl chloride (7:3, v/v) and separated by LC equipped with C18 column using acetonitrile: 5 mmol/L ammonium formate (4:3, v/v) as mobile phase. Detection is carried out on an API 2000 MS system by multiple reactions monitoring mode. The ionization was optimized using ESI(+) and selectivity was achieved by MS-MS analysis, mlz 330.0-->192.0 and m/ z 310-->148 for paroxetine and fluoxetine, respectively. The method has a total run time of 1.5 min and was linear over a working range of 0.05-20 ng/mL and the lower limit of quantification was 0.05 ng/ mL. No endogenous compounds were found to interfere with the analysis. The inter-day and intra-day accuracy was in the ranges of 102.69-107.79% and 102.07-109.57%, respectively and precision of inter-day and intra-day expressed as relative standard deviation were 1.86-9.99% and 1.52-6.28%, respectively. The validation of this method on linearity, specificity, accuracy, precision as well as applicability to pharmacokinetic and bioequivalence studies by analysis of blood samples taken up to 72 h after oral administration of 20 mg of paroxetine in 24 healthy volunteers were found to be good performance. | lld:pubmed |
| pubmed-article:17803058 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17803058 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17803058 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17803058 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17803058 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17803058 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17803058 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17803058 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17803058 | pubmed:issn | 0004-4172 | lld:pubmed |
| pubmed-article:17803058 | pubmed:author | pubmed-author:LeeSeung... | lld:pubmed |
| pubmed-article:17803058 | pubmed:author | pubmed-author:ShawLeslie... | lld:pubmed |
| pubmed-article:17803058 | pubmed:author | pubmed-author:KangJu SeopJS | lld:pubmed |
| pubmed-article:17803058 | pubmed:author | pubmed-author:KimKwang-Hyun... | lld:pubmed |
| pubmed-article:17803058 | pubmed:author | pubmed-author:LeeMin HoMH | lld:pubmed |
| pubmed-article:17803058 | pubmed:author | pubmed-author:JeonYong... | lld:pubmed |
| pubmed-article:17803058 | pubmed:author | pubmed-author:JheeOk HwaOH | lld:pubmed |
| pubmed-article:17803058 | pubmed:author | pubmed-author:LeeSeo EunSE | lld:pubmed |
| pubmed-article:17803058 | pubmed:author | pubmed-author:SeoHee... | lld:pubmed |
| pubmed-article:17803058 | pubmed:author | pubmed-author:HurYeonY | lld:pubmed |
| pubmed-article:17803058 | pubmed:author | pubmed-author:LeeHeon-SooHS | lld:pubmed |
| pubmed-article:17803058 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17803058 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:17803058 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17803058 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17803058 | pubmed:pagination | 455-61 | lld:pubmed |
| pubmed-article:17803058 | pubmed:meshHeading | pubmed-meshheading:17803058... | lld:pubmed |
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| pubmed-article:17803058 | pubmed:meshHeading | pubmed-meshheading:17803058... | lld:pubmed |
| pubmed-article:17803058 | pubmed:meshHeading | pubmed-meshheading:17803058... | lld:pubmed |
| pubmed-article:17803058 | pubmed:meshHeading | pubmed-meshheading:17803058... | lld:pubmed |
| pubmed-article:17803058 | pubmed:meshHeading | pubmed-meshheading:17803058... | lld:pubmed |
| pubmed-article:17803058 | pubmed:meshHeading | pubmed-meshheading:17803058... | lld:pubmed |
| pubmed-article:17803058 | pubmed:meshHeading | pubmed-meshheading:17803058... | lld:pubmed |
| pubmed-article:17803058 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17803058 | pubmed:articleTitle | Determination of paroxetine in plasma by liquid chromatography coupled to tandem mass spectrometry for pharmacokinetic and bioequivalence studies. | lld:pubmed |
| pubmed-article:17803058 | pubmed:affiliation | Department of Practical Arts Education, Gongju National University of Education, Gongju, Chungnam, South Korea. | lld:pubmed |
| pubmed-article:17803058 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17803058 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
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