Linked Life Data

1776859

Source:http://linkedlifedata.com/resource/pubmed/id/1776859

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pubmed-article:1776859pubmed:abstractTextIn breast tumor cell lines, c-myc amplification is frequently associated with estrogen unresponsiveness. We, however, succeeded in characterizing an estrogen-responsive cell line VHB1 derived from a duct cell carcinoma, which exhibits c-myc amplification and overexpression. We therefore studied the effects of estrogen and antiestrogen on c-myc expression in this particular cell line. We also investigated these effects on the expression of c-mil and c-myb oncogenes, also expressed but not amplified in VHB1 cells. Short-(1 h) and long-(72 h) term stimulations were performed. Our experiments showed that estradiol (E2 10(-8) M) was still able to stimulate c-myc expression equally either after short or long-term treatment. In the same way, the antiestrogen 4-hydroxytamoxifen equally decreased c-myc expression but the reversal effect of E2 after long-term antiestrogen treatment was more pronounced than after short-term treatment. The effects of E2 and 4-OH Tam on the expression of the not-amplified c-mil and c-myb oncogenes were stronger than those observed on c-myc expression; however, the E2 reversal effect was identical either after short or long-term antiestrogen treatment. Our results may enlighten some aspects of the complex action of some of the early- and late-growth regulated genes in breast cancer.lld:pubmed
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pubmed-article:1776859pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:1776859pubmed:articleTitleC-myc overexpression, c-mil, c-myb expression in a breast tumor cell line. Effects of estrogen and antiestrogen.lld:pubmed
pubmed-article:1776859pubmed:affiliationU 124 INSERM, Lille, France.lld:pubmed
pubmed-article:1776859pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1776859pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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