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pubmed-article:17766714pubmed:abstractTextThe incidence of childhood obesity and type 2 diabetes has reached epidemic proportions. Glucocorticoid excess causes central obesity and diabetes mellitus as seen in Cushing's syndrome. The 11beta-hydroxysteroid dehydrogenase type 1 enzyme (11beta-HSD1) regenerates active cortisol from inactive cortisone. Altered 11beta-HSD1 may cause tissue-specific Cushing's syndrome with central obesity and impaired glucose homeostasis.lld:pubmed
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pubmed-article:17766714pubmed:articleTitleReduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.lld:pubmed
pubmed-article:17766714pubmed:affiliationPaediatric Endocrinology, Campus Virchow, Charité University Medicine Berlin, 13353, Berlin, Germany.lld:pubmed
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