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pubmed-article:17761035pubmed:abstractTextPatients with inherited disorders of amino acid metabolism including maple syrup urine disease, tyrosinaemia and phenylketonuria on dietary management require frequent monitoring of disease-relevant plasma amino acids in order to optimize therapeutic benefit. Poorly controlled maple syrup urine disease in particular may result in catastrophic metabolic decompensation. Most methods for monitoring amino acid concentrations are time-consuming and have clinically impractical turnaround times, particularly when the required time to run standards and control samples is taken into account.lld:pubmed
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pubmed-article:17761035pubmed:articleTitleA rapid ultra performance liquid chromatography tandem mass spectrometric method for measuring amino acids associated with maple syrup urine disease, tyrosinaemia and phenylketonuria.lld:pubmed
pubmed-article:17761035pubmed:affiliationWaters Corporation, Milford, MA, USA.lld:pubmed
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