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pubmed-article:17727703pubmed:abstractTextMost genetic disorders are linked to missense mutations as even minor changes in the size or properties of an amino acid can alter or prevent the function of the protein. Further, the effect of a mutation is also dependent on the sequence and structure context of the alteration.lld:pubmed
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pubmed-article:17727703pubmed:authorpubmed-author:VihinenMaunoMlld:pubmed
pubmed-article:17727703pubmed:authorpubmed-author:KhanSofiaSlld:pubmed
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pubmed-article:17727703pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:17727703pubmed:articleTitleSpectrum of disease-causing mutations in protein secondary structures.lld:pubmed
pubmed-article:17727703pubmed:affiliationInstitute of Medical Technology, FI-33014 University of Tampere, Finland. sofia.khan@uta.filld:pubmed
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