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pubmed-article:17727295pubmed:abstractTextC2-symmetric chiral bisformamides have been shown to catalyze the asymmetric one-pot, three-component Strecker reaction, which produced the alpha-amino nitriles in excellent yields (up to 99%) with good enantioselectivities (up to 86% ee). Optically pure products could be obtained after a single recrystallization. A possible transition state (TS 1) has been proposed to explain the origin of asymmetric inductivity and reactivity according to the geometry of catalyst 2a optimized at the B3LYP/6-31G(d) level and the absolute configuration of product 4a.lld:pubmed
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pubmed-article:17727295pubmed:issn0022-3263lld:pubmed
pubmed-article:17727295pubmed:authorpubmed-author:FengXiaomingXlld:pubmed
pubmed-article:17727295pubmed:authorpubmed-author:LuChangClld:pubmed
pubmed-article:17727295pubmed:authorpubmed-author:XiongYanYlld:pubmed
pubmed-article:17727295pubmed:authorpubmed-author:LiuXiaohuaXlld:pubmed
pubmed-article:17727295pubmed:authorpubmed-author:WenYuehongYlld:pubmed
pubmed-article:17727295pubmed:authorpubmed-author:HuangJinglunJlld:pubmed
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pubmed-article:17727295pubmed:year2007lld:pubmed
pubmed-article:17727295pubmed:articleTitleChiral bisformamides as effective organocatalysts for the asymmetric one-pot, three-component strecker reaction.lld:pubmed
pubmed-article:17727295pubmed:affiliationKey Laboratory of Green Chemistry & Technology (Sichuan University), Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.lld:pubmed
pubmed-article:17727295pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17727295pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed