| pubmed-article:17723304 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17723304 | lifeskim:mentions | umls-concept:C0033809 | lld:lifeskim |
| pubmed-article:17723304 | lifeskim:mentions | umls-concept:C0007732 | lld:lifeskim |
| pubmed-article:17723304 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:17723304 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:17723304 | lifeskim:mentions | umls-concept:C0038477 | lld:lifeskim |
| pubmed-article:17723304 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:17723304 | lifeskim:mentions | umls-concept:C1518896 | lld:lifeskim |
| pubmed-article:17723304 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:17723304 | lifeskim:mentions | umls-concept:C0205549 | lld:lifeskim |
| pubmed-article:17723304 | lifeskim:mentions | umls-concept:C0450254 | lld:lifeskim |
| pubmed-article:17723304 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:17723304 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:17723304 | pubmed:dateCreated | 2007-9-17 | lld:pubmed |
| pubmed-article:17723304 | pubmed:abstractText | A series of 7beta-[2-(2-aminothiazol-4-yl)-2-(Z)-(carboxymethoxyimino)acetamido]cephalosporins bearing a 1-(substituted)-1H-pyrrolo[3,2-b]pyridinium group at C-3' position was synthesized and their in vitro antibacterial activities against Pseudomonas aeruginosa and other Gram-negative pathogens were evaluated. Among the cephalosporins prepared, 7beta-[2-(2-amino-5-chlorothiazol-4yl)-2(Z)-((S)-1-carboxyethoxyimino)acetamido]cephalosporins (42d) showed potent antibacterial activities against P. aeruginosa and other Gram-negative pathogens including the strains which produce class C beta-lactamase and extended spectrum beta-lactamase (ESBL). These results imply that both the Cl atom on the C-7 aminothiazole moiety and the alpha-substituent at the iminoether moiety are essential for the stability against beta-lactamase and the potent activity against Gram-negative bacteria including P. aeruginosa. | lld:pubmed |
| pubmed-article:17723304 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17723304 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17723304 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17723304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17723304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17723304 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17723304 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17723304 | pubmed:issn | 0968-0896 | lld:pubmed |
| pubmed-article:17723304 | pubmed:author | pubmed-author:NomuraTakashi... | lld:pubmed |
| pubmed-article:17723304 | pubmed:author | pubmed-author:TakedaKeiK | lld:pubmed |
| pubmed-article:17723304 | pubmed:author | pubmed-author:YamawakiKenji... | lld:pubmed |
| pubmed-article:17723304 | pubmed:author | pubmed-author:MiwaHideakiH | lld:pubmed |
| pubmed-article:17723304 | pubmed:author | pubmed-author:YasukataTatsu... | lld:pubmed |
| pubmed-article:17723304 | pubmed:author | pubmed-author:NishitaniYasu... | lld:pubmed |
| pubmed-article:17723304 | pubmed:author | pubmed-author:UotaniKoichiK | lld:pubmed |
| pubmed-article:17723304 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17723304 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17723304 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:17723304 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17723304 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17723304 | pubmed:pagination | 6716-32 | lld:pubmed |
| pubmed-article:17723304 | pubmed:meshHeading | pubmed-meshheading:17723304... | lld:pubmed |
| pubmed-article:17723304 | pubmed:meshHeading | pubmed-meshheading:17723304... | lld:pubmed |
| pubmed-article:17723304 | pubmed:meshHeading | pubmed-meshheading:17723304... | lld:pubmed |
| pubmed-article:17723304 | pubmed:meshHeading | pubmed-meshheading:17723304... | lld:pubmed |
| pubmed-article:17723304 | pubmed:meshHeading | pubmed-meshheading:17723304... | lld:pubmed |
| pubmed-article:17723304 | pubmed:meshHeading | pubmed-meshheading:17723304... | lld:pubmed |
| pubmed-article:17723304 | pubmed:meshHeading | pubmed-meshheading:17723304... | lld:pubmed |
| pubmed-article:17723304 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17723304 | pubmed:articleTitle | A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: synthesis and structure-activity relationships. | lld:pubmed |
| pubmed-article:17723304 | pubmed:affiliation | Discovery Research Laboratories, Shionogi & Co Ltd, 12-4, Sagisu 5-Chome, Osaka, Japan. kenji.yamawaki@shionogi.co.jp | lld:pubmed |
| pubmed-article:17723304 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17723304 | lld:chembl |
