| pubmed-article:17719584 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17719584 | lifeskim:mentions | umls-concept:C0043167 | lld:lifeskim |
| pubmed-article:17719584 | lifeskim:mentions | umls-concept:C1140680 | lld:lifeskim |
| pubmed-article:17719584 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17719584 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:17719584 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:17719584 | lifeskim:mentions | umls-concept:C0682972 | lld:lifeskim |
| pubmed-article:17719584 | lifeskim:mentions | umls-concept:C2699153 | lld:lifeskim |
| pubmed-article:17719584 | lifeskim:mentions | umls-concept:C1269955 | lld:lifeskim |
| pubmed-article:17719584 | lifeskim:mentions | umls-concept:C0600210 | lld:lifeskim |
| pubmed-article:17719584 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:17719584 | lifeskim:mentions | umls-concept:C0065389 | lld:lifeskim |
| pubmed-article:17719584 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:17719584 | pubmed:dateCreated | 2007-9-11 | lld:pubmed |
| pubmed-article:17719584 | pubmed:abstractText | We investigated whether lysophosphatidylethanolamine (LPE) modulates cellular signaling in different cell types. SK-OV3 ovarian cancer cells and OVCAR-3 ovarian cancer cells were responsive to LPE. LPE-stimulated intracellular calcium concentration ([Ca(2+)](i)) increase was inhibited by U-73122, suggesting that LPE stimulates calcium signaling via phospholipase C activation. Moreover, pertussis toxin (PTX) almost completely inhibited [Ca(2+)](i) increase by LPE, indicating the involvement of PTX-sensitive G-proteins. Furthermore, we found that LPE stimulated chemotactic migration and cellular invasion in SK-OV3 ovarian cancer cells. We examined the role of lysophosphatidic acid receptors on LPE-stimulated cellular responses using HepG2 cells transfected with different LPA receptors, and found that LPE failed to stimulate nuclear factor kappa B-driven luciferase. We suggest that LPE stimulates a membrane bound receptor, different from well known LPA receptors, resulting in chemotactic migration and cellular invasion in SK-OV3 ovarian cancer cells. | lld:pubmed |
| pubmed-article:17719584 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17719584 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17719584 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17719584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17719584 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17719584 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17719584 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:17719584 | pubmed:author | pubmed-author:BaeYoe-SikYS | lld:pubmed |
| pubmed-article:17719584 | pubmed:author | pubmed-author:KimJung MoJM | lld:pubmed |
| pubmed-article:17719584 | pubmed:author | pubmed-author:LeeSun... | lld:pubmed |
| pubmed-article:17719584 | pubmed:author | pubmed-author:ImDong-SoonDS | lld:pubmed |
| pubmed-article:17719584 | pubmed:author | pubmed-author:YunJeanhoJ | lld:pubmed |
| pubmed-article:17719584 | pubmed:author | pubmed-author:ParkKyoung... | lld:pubmed |
| pubmed-article:17719584 | pubmed:author | pubmed-author:LeeHa YoungHY | lld:pubmed |
| pubmed-article:17719584 | pubmed:author | pubmed-author:KimMi-KyoungM... | lld:pubmed |
| pubmed-article:17719584 | pubmed:author | pubmed-author:KimSang DooSD | lld:pubmed |
| pubmed-article:17719584 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17719584 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:17719584 | pubmed:volume | 581 | lld:pubmed |
| pubmed-article:17719584 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17719584 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17719584 | pubmed:pagination | 4411-6 | lld:pubmed |
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| pubmed-article:17719584 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17719584 | pubmed:articleTitle | Lysophosphatidylethanolamine stimulates chemotactic migration and cellular invasion in SK-OV3 human ovarian cancer cells: involvement of pertussis toxin-sensitive G-protein coupled receptor. | lld:pubmed |
| pubmed-article:17719584 | pubmed:affiliation | Department of Biochemistry, College of Medicine, Dong-A University, Busan 602-714, Republic of Korea. | lld:pubmed |
| pubmed-article:17719584 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17719584 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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