| pubmed-article:17712314 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17712314 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:17712314 | lifeskim:mentions | umls-concept:C0238463 | lld:lifeskim |
| pubmed-article:17712314 | lifeskim:mentions | umls-concept:C0851346 | lld:lifeskim |
| pubmed-article:17712314 | lifeskim:mentions | umls-concept:C0205422 | lld:lifeskim |
| pubmed-article:17712314 | lifeskim:mentions | umls-concept:C0752248 | lld:lifeskim |
| pubmed-article:17712314 | lifeskim:mentions | umls-concept:C1705535 | lld:lifeskim |
| pubmed-article:17712314 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17712314 | pubmed:dateCreated | 2007-9-12 | lld:pubmed |
| pubmed-article:17712314 | pubmed:abstractText | Papillary thyroid cancers (PTCs) incidence dramatically increased in the vicinity of Chernobyl. The cancer-initiating role of radiation elsewhere is debated. Therefore, we searched for a signature distinguishing radio-induced from sporadic cancers. Using microarrays, we compared the expression profiles of PTCs from the Chernobyl Tissue Bank (CTB, n=12) and from French patients with no history of exposure to ionising radiations (n=14). We also compared the transcriptional responses of human lymphocytes to the presumed aetiological agents initiating these tumours, gamma-radiation and H(2)O(2). On a global scale, the transcriptomes of CTB and French tumours are indistinguishable, and the transcriptional responses to gamma-radiation and H(2)O(2) are similar. On a finer scale, a 118 genes signature discriminated the gamma-radiation and H(2)O(2) responses. This signature could be used to classify the tumours as CTB or French with an error of 15-27%. Similar results were obtained with an independent signature of 13 genes involved in homologous recombination. Although sporadic and radio-induced PTCs represent the same disease, they are distinguishable with molecular signatures reflecting specific responses to gamma-radiation and H(2)O(2). These signatures in PTCs could reflect the susceptibility profiles of the patients, suggesting the feasibility of a radiation susceptibility test. | lld:pubmed |
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| pubmed-article:17712314 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17712314 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17712314 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17712314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17712314 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17712314 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17712314 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:17712314 | pubmed:author | pubmed-author:DumontJ EJE | lld:pubmed |
| pubmed-article:17712314 | pubmed:author | pubmed-author:ThomasGG | lld:pubmed |
| pubmed-article:17712314 | pubmed:author | pubmed-author:FrantSS | lld:pubmed |
| pubmed-article:17712314 | pubmed:author | pubmed-author:MaenhautCC | lld:pubmed |
| pubmed-article:17712314 | pubmed:author | pubmed-author:LibertFF | lld:pubmed |
| pubmed-article:17712314 | pubmed:author | pubmed-author:DetoursVV | lld:pubmed |
| pubmed-article:17712314 | pubmed:author | pubmed-author:BogdanovaTT | lld:pubmed |
| pubmed-article:17712314 | pubmed:author | pubmed-author:DelysLL | lld:pubmed |
| pubmed-article:17712314 | pubmed:author | pubmed-author:Weiss SolísDD | lld:pubmed |
| pubmed-article:17712314 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17712314 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:17712314 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:17712314 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17712314 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17712314 | pubmed:pagination | 818-25 | lld:pubmed |
| pubmed-article:17712314 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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