| pubmed-article:17706843 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17706843 | lifeskim:mentions | umls-concept:C0206679 | lld:lifeskim |
| pubmed-article:17706843 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:17706843 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17706843 | lifeskim:mentions | umls-concept:C0328767 | lld:lifeskim |
| pubmed-article:17706843 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:17706843 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17706843 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:17706843 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:17706843 | lifeskim:mentions | umls-concept:C0205322 | lld:lifeskim |
| pubmed-article:17706843 | lifeskim:mentions | umls-concept:C1817908 | lld:lifeskim |
| pubmed-article:17706843 | lifeskim:mentions | umls-concept:C0086022 | lld:lifeskim |
| pubmed-article:17706843 | lifeskim:mentions | umls-concept:C1705099 | lld:lifeskim |
| pubmed-article:17706843 | lifeskim:mentions | umls-concept:C0442335 | lld:lifeskim |
| pubmed-article:17706843 | pubmed:issue | 37-38 | lld:pubmed |
| pubmed-article:17706843 | pubmed:dateCreated | 2007-9-7 | lld:pubmed |
| pubmed-article:17706843 | pubmed:abstractText | We have constructed a replication competent, gamma(1)34.5-deleted herpes simplex virus type-1 (HSV-1) vector (J200) that expresses the gag gene from human immunodeficiency virus type-1, primary isolate 89.6 (HIV-1(89.6)), as a candidate vaccine for HIV-1. J200 replicates in vitro, resulting in abundant Gag protein production and accumulation in the extracellular media. Immunization of Balb/c mice with a single intraperitoneal injection of J200 elicited strong Gag-specific CD8 responses, as measured by intracellular IFN-gamma staining and flow cytometry analysis. Responses were highest between 6 weeks and 4 months, but persisted at 9 months post-immunization, the last time-point evaluated. These data highlight the potential utility of neuroattenuated, replication competent HSV-1 vectors for delivery of HIV-1 immunogens. | lld:pubmed |
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| pubmed-article:17706843 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17706843 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17706843 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17706843 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17706843 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17706843 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17706843 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:17706843 | pubmed:author | pubmed-author:MaysD MDM | lld:pubmed |
| pubmed-article:17706843 | pubmed:author | pubmed-author:HunterEricE | lld:pubmed |
| pubmed-article:17706843 | pubmed:author | pubmed-author:WhitleyRichar... | lld:pubmed |
| pubmed-article:17706843 | pubmed:author | pubmed-author:ZajacAllan... | lld:pubmed |
