| pubmed-article:17706597 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17706597 | lifeskim:mentions | umls-concept:C1384616 | lld:lifeskim |
| pubmed-article:17706597 | lifeskim:mentions | umls-concept:C2347318 | lld:lifeskim |
| pubmed-article:17706597 | lifeskim:mentions | umls-concept:C0032008 | lld:lifeskim |
| pubmed-article:17706597 | lifeskim:mentions | umls-concept:C0033371 | lld:lifeskim |
| pubmed-article:17706597 | lifeskim:mentions | umls-concept:C0037663 | lld:lifeskim |
| pubmed-article:17706597 | lifeskim:mentions | umls-concept:C0084785 | lld:lifeskim |
| pubmed-article:17706597 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:17706597 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17706597 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17706597 | pubmed:dateCreated | 2007-8-29 | lld:pubmed |
| pubmed-article:17706597 | pubmed:abstractText | Thyroid transcription factor 1 (TTF-1) is required for morphogenesis of the fetal diencephalon. Previous reports showed that mice carrying a TTF-1 null mutation lacked normal development of the pituitary gland. In this study, a role for TTF-1 in the regulation of growth hormone and prolactin transcription was identified. In-situ hybridization analysis demonstrated TTF-1 mRNA in the growth hormone-producing cells and prolactin-producing cells of the rat anterior pituitary gland. In the GH3 pituitary cell line, we identified TTF-1 as a factor functionally regulating growth hormone and prolactin transcription. TTF-1 activated prolactin transcription, but inhibited growth hormone transcription. Inhibition and activation of growth hormone and prolactin transcription, respectively, by TTF-1 disappeared upon deletion of the TTF-1 binding motifs within the promoters of these genes. These data suggest that TTF-1 plays a regulatory role in the transcription of growth hormone and prolactin genes and may regulate transdifferentiation of cells expressing these two hormones. | lld:pubmed |
| pubmed-article:17706597 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17706597 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17706597 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17706597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17706597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17706597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17706597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17706597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17706597 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17706597 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17706597 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:17706597 | pubmed:author | pubmed-author:DamanteGiusep... | lld:pubmed |
| pubmed-article:17706597 | pubmed:author | pubmed-author:HaChang ManCM | lld:pubmed |
| pubmed-article:17706597 | pubmed:author | pubmed-author:SonYoung... | lld:pubmed |
| pubmed-article:17706597 | pubmed:author | pubmed-author:LeeByung JuBJ | lld:pubmed |
| pubmed-article:17706597 | pubmed:author | pubmed-author:D'EliaAngela... | lld:pubmed |
| pubmed-article:17706597 | pubmed:author | pubmed-author:ParkJeong... | lld:pubmed |
| pubmed-article:17706597 | pubmed:author | pubmed-author:YunChang HoCH | lld:pubmed |
| pubmed-article:17706597 | pubmed:author | pubmed-author:KimJae GeunJG | lld:pubmed |
| pubmed-article:17706597 | pubmed:author | pubmed-author:LeeNam OakNO | lld:pubmed |
| pubmed-article:17706597 | pubmed:author | pubmed-author:LimHye LiHL | lld:pubmed |
| pubmed-article:17706597 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17706597 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:17706597 | pubmed:volume | 362 | lld:pubmed |
| pubmed-article:17706597 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17706597 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17706597 | pubmed:pagination | 193-9 | lld:pubmed |
| pubmed-article:17706597 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:17706597 | pubmed:meshHeading | pubmed-meshheading:17706597... | lld:pubmed |
| pubmed-article:17706597 | pubmed:meshHeading | pubmed-meshheading:17706597... | lld:pubmed |
| pubmed-article:17706597 | pubmed:meshHeading | pubmed-meshheading:17706597... | lld:pubmed |
| pubmed-article:17706597 | pubmed:meshHeading | pubmed-meshheading:17706597... | lld:pubmed |
| pubmed-article:17706597 | pubmed:meshHeading | pubmed-meshheading:17706597... | lld:pubmed |
| pubmed-article:17706597 | pubmed:meshHeading | pubmed-meshheading:17706597... | lld:pubmed |
| pubmed-article:17706597 | pubmed:meshHeading | pubmed-meshheading:17706597... | lld:pubmed |
| pubmed-article:17706597 | pubmed:meshHeading | pubmed-meshheading:17706597... | lld:pubmed |
| pubmed-article:17706597 | pubmed:meshHeading | pubmed-meshheading:17706597... | lld:pubmed |
| pubmed-article:17706597 | pubmed:meshHeading | pubmed-meshheading:17706597... | lld:pubmed |
| pubmed-article:17706597 | pubmed:meshHeading | pubmed-meshheading:17706597... | lld:pubmed |
| pubmed-article:17706597 | pubmed:meshHeading | pubmed-meshheading:17706597... | lld:pubmed |
| pubmed-article:17706597 | pubmed:meshHeading | pubmed-meshheading:17706597... | lld:pubmed |
| pubmed-article:17706597 | pubmed:meshHeading | pubmed-meshheading:17706597... | lld:pubmed |
| pubmed-article:17706597 | pubmed:meshHeading | pubmed-meshheading:17706597... | lld:pubmed |
| pubmed-article:17706597 | pubmed:meshHeading | pubmed-meshheading:17706597... | lld:pubmed |
| pubmed-article:17706597 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17706597 | pubmed:articleTitle | TTF-1 regulates growth hormone and prolactin transcription in the anterior pituitary gland. | lld:pubmed |
| pubmed-article:17706597 | pubmed:affiliation | Department of Biological Sciences, College of Natural Sciences, University of Ulsan, Ulsan 680-749, Republic of Korea. | lld:pubmed |
| pubmed-article:17706597 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17706597 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:24391 | entrezgene:pubmed | pubmed-article:17706597 | lld:entrezgene |
| entrez-gene:24683 | entrezgene:pubmed | pubmed-article:17706597 | lld:entrezgene |
| entrez-gene:25628 | entrezgene:pubmed | pubmed-article:17706597 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17706597 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17706597 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17706597 | lld:entrezgene |
