| pubmed-article:17696417 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17696417 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:17696417 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:17696417 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:17696417 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:17696417 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:17696417 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:17696417 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:17696417 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:17696417 | lifeskim:mentions | umls-concept:C0032743 | lld:lifeskim |
| pubmed-article:17696417 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:17696417 | lifeskim:mentions | umls-concept:C1522485 | lld:lifeskim |
| pubmed-article:17696417 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:17696417 | pubmed:dateCreated | 2007-8-30 | lld:pubmed |
| pubmed-article:17696417 | pubmed:abstractText | A series of fluorinated chromone analogs with IC50 values ranging from 9 to 133 nM for the mitochondrial complex 1 (MC-I) has been prepared. A structure-activity relationship (SAR) study of the most potent fluorinated chromone analog 10 demonstrated the linkage heteroatom preference of the side chain region of the molecule while maintaining potent MC-I inhibitory activity. Tissue distribution studies 30 min after [(18)F]10 administration to Sprague-Dawley (SD) rats demonstrated high uptake of the radiotracer from the blood pool into the myocardium (2.24% ID/g), kidney (1.93% ID/g), and liver (2.00% ID/g). After 2 h about 66% of the activity in the myocardium at 30 min had been retained, whereas approximately 70% had been cleared from the liver and kidney. MicroPET images of SD rats after [(18)F]10 administration allowed easy assessment of the myocardium through 60 min with minimal lung or liver interference. | lld:pubmed |
| pubmed-article:17696417 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17696417 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17696417 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17696417 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17696417 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17696417 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17696417 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17696417 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17696417 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17696417 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17696417 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17696417 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:17696417 | pubmed:author | pubmed-author:YuMingM | lld:pubmed |
| pubmed-article:17696417 | pubmed:author | pubmed-author:RobinsonSimon... | lld:pubmed |
| pubmed-article:17696417 | pubmed:author | pubmed-author:YalamanchiliP... | lld:pubmed |
| pubmed-article:17696417 | pubmed:author | pubmed-author:ZhangZhi-QinZ... | lld:pubmed |
| pubmed-article:17696417 | pubmed:author | pubmed-author:GuaraldiMaryM | lld:pubmed |
| pubmed-article:17696417 | pubmed:author | pubmed-author:HansonKelleyK | lld:pubmed |
| pubmed-article:17696417 | pubmed:author | pubmed-author:AzureMichaelM | lld:pubmed |
| pubmed-article:17696417 | pubmed:author | pubmed-author:KaganMikhailM | lld:pubmed |
| pubmed-article:17696417 | pubmed:author | pubmed-author:HayesMeganM | lld:pubmed |
| pubmed-article:17696417 | pubmed:author | pubmed-author:CasebierDavid... | lld:pubmed |
| pubmed-article:17696417 | pubmed:author | pubmed-author:RadekeHeikeH | lld:pubmed |
| pubmed-article:17696417 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17696417 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:17696417 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:17696417 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17696417 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17696417 | pubmed:pagination | 4304-15 | lld:pubmed |
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| pubmed-article:17696417 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17696417 | pubmed:articleTitle | Synthesis and biological evaluation of the mitochondrial complex 1 inhibitor 2-[4-(4-fluorobutyl)benzylsulfanyl]-3-methylchromene-4-one as a potential cardiac positron emission tomography tracer. | lld:pubmed |
| pubmed-article:17696417 | pubmed:affiliation | Research and Development, Bristol-Myers Squibb Medical Imaging, 331 Treble Cove Road, North Billerica, Massachusetts 01862, USA. heike.radeke@bms.com | lld:pubmed |
| pubmed-article:17696417 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17696417 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17696417 | lld:chembl |
