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pubmed-article:1769287pubmed:abstractTextRates of tumor-cell proliferation often provide prognostic information about a given neoplasm. Previously available methods for accessing cell kinetics are time consuming and expensive, and often require special equipment or radioactive reagents. Monoclonal antibody Ki-67 binds a nuclear antigen expressed in proliferating but not in resting cells. We studied Ki-67 immunostaining of fine-needle aspiration smears from 40 benign and malignant masses. Labeling indices ranged from 0 (thyroid follicular adenoma) to 75 percent (pulmonary oat-cell carcinoma). Frozen section immunostaining (11 cases) and flow cytometric assessment of cell proliferation (8 cases) were in good agreement with Ki-67 labeling indices on smear material. We suggest that this method provides a rapid, inexpensive, and dependable means of assessing tumor-cell kinetics in cytologic preparations.lld:pubmed
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pubmed-article:1769287pubmed:authorpubmed-author:SwensonBBlld:pubmed
pubmed-article:1769287pubmed:authorpubmed-author:ConnollyJ EJElld:pubmed
pubmed-article:1769287pubmed:authorpubmed-author:HenryM JMJlld:pubmed
pubmed-article:1769287pubmed:authorpubmed-author:StanleyM WMWlld:pubmed
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pubmed-article:1769287pubmed:pagination591-6lld:pubmed
pubmed-article:1769287pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:1769287pubmed:articleTitleCytologic assessment of tumor cell kinetics: applications of monoclonal antibody Ki-67 to fine-needle aspiration smears.lld:pubmed
pubmed-article:1769287pubmed:affiliationDepartment of Pathology, Hennepin County Medical Center, Minneapolis, Minnesota 55415.lld:pubmed
pubmed-article:1769287pubmed:publicationTypeJournal Articlelld:pubmed