| pubmed-article:17689616 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17689616 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:17689616 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:17689616 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:17689616 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:17689616 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:17689616 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:17689616 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:17689616 | lifeskim:mentions | umls-concept:C0439611 | lld:lifeskim |
| pubmed-article:17689616 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17689616 | pubmed:dateCreated | 2007-12-17 | lld:pubmed |
| pubmed-article:17689616 | pubmed:abstractText | New Pd(II) and Pt(II) complexes [ML2] (HL=a substituted 2,5-dihydro-5-oxo-1H-pyrazolone-1-carbothioamide) have been synthesized by reacting K2MCl4 (M=Pd, Pt) or Pd(OAc)2 with beta-ketoester thiosemicarbazones. The structures of seven of these complexes were determined by X-ray diffraction. Although all exhibit a distorted square-planar coordination with trans- or (in one case) cis-[MN2S2] kernels, their supramolecular arrangements vary widely from isolated molecules to 3D-networks. The in vitro antitumoral assays performed with two HL ligands and their metal complexes showed significant cytostatic activity for the latter, with the most active [ML2] derivative (a palladium complex) being about sixteen times more active than cis-DDP against the cisplatinum-resistant cell line A2780cisR. | lld:pubmed |
| pubmed-article:17689616 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17689616 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17689616 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17689616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17689616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17689616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17689616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17689616 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17689616 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17689616 | pubmed:issn | 0162-0134 | lld:pubmed |
| pubmed-article:17689616 | pubmed:author | pubmed-author:SupersteinEE | lld:pubmed |
| pubmed-article:17689616 | pubmed:author | pubmed-author:CasasJosé SJS | lld:pubmed |
| pubmed-article:17689616 | pubmed:author | pubmed-author:EllenaJavierJ | lld:pubmed |
| pubmed-article:17689616 | pubmed:author | pubmed-author:García-Tasend... | lld:pubmed |
| pubmed-article:17689616 | pubmed:author | pubmed-author:SánchezAgustí... | lld:pubmed |
| pubmed-article:17689616 | pubmed:author | pubmed-author:SordoJoséJ | lld:pubmed |
| pubmed-article:17689616 | pubmed:author | pubmed-author:Pérez-Parallé... | lld:pubmed |
| pubmed-article:17689616 | pubmed:author | pubmed-author:Sánchez-Gonzá... | lld:pubmed |
| pubmed-article:17689616 | pubmed:author | pubmed-author:ToucedaAngele... | lld:pubmed |
| pubmed-article:17689616 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17689616 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:17689616 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17689616 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17689616 | pubmed:pagination | 33-45 | lld:pubmed |
| pubmed-article:17689616 | pubmed:meshHeading | pubmed-meshheading:17689616... | lld:pubmed |
| pubmed-article:17689616 | pubmed:meshHeading | pubmed-meshheading:17689616... | lld:pubmed |
| pubmed-article:17689616 | pubmed:meshHeading | pubmed-meshheading:17689616... | lld:pubmed |
| pubmed-article:17689616 | pubmed:meshHeading | pubmed-meshheading:17689616... | lld:pubmed |
| pubmed-article:17689616 | pubmed:meshHeading | pubmed-meshheading:17689616... | lld:pubmed |
| pubmed-article:17689616 | pubmed:meshHeading | pubmed-meshheading:17689616... | lld:pubmed |
| pubmed-article:17689616 | pubmed:meshHeading | pubmed-meshheading:17689616... | lld:pubmed |
| pubmed-article:17689616 | pubmed:meshHeading | pubmed-meshheading:17689616... | lld:pubmed |
| pubmed-article:17689616 | pubmed:meshHeading | pubmed-meshheading:17689616... | lld:pubmed |
| pubmed-article:17689616 | pubmed:meshHeading | pubmed-meshheading:17689616... | lld:pubmed |
| pubmed-article:17689616 | pubmed:meshHeading | pubmed-meshheading:17689616... | lld:pubmed |
| pubmed-article:17689616 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17689616 | pubmed:articleTitle | New Pd(II) and Pt(II) complexes with N,S-chelated pyrazolonate ligands: molecular and supramolecular structure and preliminary study of their in vitro antitumoral activity. | lld:pubmed |
| pubmed-article:17689616 | pubmed:affiliation | Departamento de Química Inorgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Galicia, Spain. qiscasas@usc.es | lld:pubmed |
| pubmed-article:17689616 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17689616 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17689616 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17689616 | lld:pubmed |
