| pubmed-article:17686504 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17686504 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:17686504 | lifeskim:mentions | umls-concept:C1335872 | lld:lifeskim |
| pubmed-article:17686504 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:17686504 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:17686504 | lifeskim:mentions | umls-concept:C1415900 | lld:lifeskim |
| pubmed-article:17686504 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:17686504 | lifeskim:mentions | umls-concept:C1533157 | lld:lifeskim |
| pubmed-article:17686504 | lifeskim:mentions | umls-concept:C0147992 | lld:lifeskim |
| pubmed-article:17686504 | lifeskim:mentions | umls-concept:C0870509 | lld:lifeskim |
| pubmed-article:17686504 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17686504 | pubmed:dateCreated | 2007-11-6 | lld:pubmed |
| pubmed-article:17686504 | pubmed:abstractText | Viruses have evolved various strategies to escape the antiviral activity of type I interferons (IFN-alpha/beta). For measles virus, this function is carried by the polycistronic gene P that encodes, by an unusual editing strategy, for the phosphoprotein P and the virulence factor V (MV-V). MV-V prevents STAT1 nuclear translocation by either sequestration or phosphorylation inhibition, thereby blocking IFN-alpha/beta pathway. We show that both the N- and C-terminal domains of MV-V (PNT and VCT) contribute to the inhibition of IFN-alpha/beta signaling. Using the two-hybrid system and co-affinity purification experiments, we identified STAT1 and Jak1 as interactors of MV-V and demonstrate that MV-V can block the direct phosphorylation of STAT1 by Jak1. A deleterious mutation within the PNT domain of MV-V (Y110H) impaired its ability to interact and block STAT1 phosphorylation. Thus, MV-V interacts with at least two components of IFN-alpha/beta receptor complex to block downstream signaling. | lld:pubmed |
| pubmed-article:17686504 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17686504 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17686504 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17686504 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17686504 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17686504 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:17686504 | pubmed:author | pubmed-author:JonesLouis... | lld:pubmed |
| pubmed-article:17686504 | pubmed:author | pubmed-author:JacobYvesY | lld:pubmed |
| pubmed-article:17686504 | pubmed:author | pubmed-author:VidalainPierr... | lld:pubmed |
| pubmed-article:17686504 | pubmed:author | pubmed-author:TangyFrédéric... | lld:pubmed |
| pubmed-article:17686504 | pubmed:author | pubmed-author:Labernardière... | lld:pubmed |
| pubmed-article:17686504 | pubmed:author | pubmed-author:WildFabianF | lld:pubmed |
| pubmed-article:17686504 | pubmed:author | pubmed-author:GuerboisMathi... | lld:pubmed |
| pubmed-article:17686504 | pubmed:author | pubmed-author:CaignardGrégo... | lld:pubmed |
| pubmed-article:17686504 | pubmed:author | pubmed-author:Infectious... | lld:pubmed |
| pubmed-article:17686504 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17686504 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:17686504 | pubmed:volume | 368 | lld:pubmed |
| pubmed-article:17686504 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17686504 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17686504 | pubmed:pagination | 351-62 | lld:pubmed |
| pubmed-article:17686504 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:17686504 | pubmed:meshHeading | pubmed-meshheading:17686504... | lld:pubmed |
| pubmed-article:17686504 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17686504 | pubmed:articleTitle | Measles virus V protein blocks Jak1-mediated phosphorylation of STAT1 to escape IFN-alpha/beta signaling. | lld:pubmed |
| pubmed-article:17686504 | pubmed:affiliation | Laboratoire de Génomique Virale et Vaccination, CNRS URA 3015, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris Cedex 15, France. | lld:pubmed |
| pubmed-article:17686504 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17686504 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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