pubmed-article:17641067 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17641067 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
pubmed-article:17641067 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
pubmed-article:17641067 | lifeskim:mentions | umls-concept:C0524914 | lld:lifeskim |
pubmed-article:17641067 | lifeskim:mentions | umls-concept:C0040549 | lld:lifeskim |
pubmed-article:17641067 | lifeskim:mentions | umls-concept:C0011209 | lld:lifeskim |
pubmed-article:17641067 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
pubmed-article:17641067 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:17641067 | pubmed:dateCreated | 2007-7-20 | lld:pubmed |
pubmed-article:17641067 | pubmed:abstractText | Expression of chemokine receptors by tumors, specifically CCR4 on cutaneous T cell lymphomas, is often associated with a poor disease outcome. To test the hypothesis that chemokine receptor-expressing tumors can be successfully controlled by delivering toxins through their chemokine receptors, we have generated fusion proteins designated chemotoxins: chemokines fused with toxic moieties that are nontoxic unless delivered into the cell cytosol. We demonstrate that chemokines fused with human RNase eosinophil-derived neurotoxin or with a truncated fragment of Pseudomonas exotoxin 38 are able to specifically kill tumors in vitro upon internalization through their respective chemokine receptors. Moreover, treatment with the thymus and activation-regulated chemokine (CCL17)-expressing chemotoxin efficiently eradicated CCR4-expressing cutaneous T cell lymphoma/leukemia established in NOD-SCID mice. Taken together, this work represents a novel concept that may allow control of growth and dissemination of tumors that use chemokine receptors to metastasize and circumvent immunosurveillance. | lld:pubmed |
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pubmed-article:17641067 | pubmed:language | eng | lld:pubmed |
pubmed-article:17641067 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17641067 | pubmed:citationSubset | AIM | lld:pubmed |
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pubmed-article:17641067 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17641067 | pubmed:month | Aug | lld:pubmed |
pubmed-article:17641067 | pubmed:issn | 0022-1767 | lld:pubmed |
pubmed-article:17641067 | pubmed:author | pubmed-author:BaatarDolgorD | lld:pubmed |
pubmed-article:17641067 | pubmed:author | pubmed-author:BiragynAryaA | lld:pubmed |
pubmed-article:17641067 | pubmed:author | pubmed-author:SumitomoKenya... | lld:pubmed |
pubmed-article:17641067 | pubmed:author | pubmed-author:OlkhanudPurev... | lld:pubmed |
pubmed-article:17641067 | pubmed:author | pubmed-author:NewtonDianneD | lld:pubmed |
pubmed-article:17641067 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:17641067 | pubmed:day | 1 | lld:pubmed |
pubmed-article:17641067 | pubmed:volume | 179 | lld:pubmed |
pubmed-article:17641067 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17641067 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17641067 | pubmed:pagination | 1996-2004 | lld:pubmed |
pubmed-article:17641067 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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