| pubmed-article:17638898 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17638898 | lifeskim:mentions | umls-concept:C0001483 | lld:lifeskim |
| pubmed-article:17638898 | lifeskim:mentions | umls-concept:C0017296 | lld:lifeskim |
| pubmed-article:17638898 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:17638898 | lifeskim:mentions | umls-concept:C1140618 | lld:lifeskim |
| pubmed-article:17638898 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:17638898 | lifeskim:mentions | umls-concept:C0919437 | lld:lifeskim |
| pubmed-article:17638898 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:17638898 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:17638898 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17638898 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:17638898 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:17638898 | lifeskim:mentions | umls-concept:C1518581 | lld:lifeskim |
| pubmed-article:17638898 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:17638898 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:17638898 | pubmed:dateCreated | 2007-7-19 | lld:pubmed |
| pubmed-article:17638898 | pubmed:abstractText | There is a need for novel therapies targeting hypoxic cells in tumors. These cells are associated with tumor resistance to therapy and express hypoxia inducible factor-1 (HIF-1), a transcription factor that mediates metabolic adaptation to hypoxia and activates tumor angiogenesis. We previously developed an oncolytic adenovirus (HYPR-Ad) for the specific killing of hypoxic/HIF-active tumor cells, which we now armed with an interleukin-4 gene (HYPR-Ad-IL4). We designed HYPR-Ad-IL4 by cloning the Ad E1A viral replication and IL-4 genes under the regulation of a bidirectional hypoxia/HIF-responsive promoter. The IL-4 cytokine was chosen for its ability to induce a strong host antitumor immune response and its potential antiangiogenic activity. HYPR-Ad-IL4 induced hypoxia-dependent IL-4 expression, viral replication, and conditional cytolysis of hypoxic, but not normoxic cells. The treatment of established human tumor xenografts with HYPR-Ad-IL4 resulted in rapid and maintained tumor regression with the same potency as that of wild-type dl309-Ad. HYPR-Ad-IL4-treated tumors displayed extensive necrosis, fibrosis, and widespread viral replication. Additionally, these tumors contained a distinctive leukocyte infiltrate and prominent hypoxia. The use of an oncolytic Ad that locally delivers IL-4 to tumors is novel, and we expect that HYPR-Ad-IL4 will have broad therapeutic use for all solid tumors that have hypoxia or active HIF, regardless of tissue origin or genetic alterations. | lld:pubmed |
| pubmed-article:17638898 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17638898 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17638898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17638898 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17638898 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17638898 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:17638898 | pubmed:author | pubmed-author:BratDaniel... | lld:pubmed |
| pubmed-article:17638898 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:17638898 | pubmed:author | pubmed-author:PostDawn EDE | lld:pubmed |
| pubmed-article:17638898 | pubmed:author | pubmed-author:SandbergEric... | lld:pubmed |
| pubmed-article:17638898 | pubmed:author | pubmed-author:XuZhihengZ | lld:pubmed |
| pubmed-article:17638898 | pubmed:author | pubmed-author:KyleMichele... | lld:pubmed |
| pubmed-article:17638898 | pubmed:author | pubmed-author:DeviNarra... | lld:pubmed |
| pubmed-article:17638898 | pubmed:author | pubmed-author:TighiouartMou... | lld:pubmed |
| pubmed-article:17638898 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17638898 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17638898 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:17638898 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17638898 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17638898 | pubmed:pagination | 6872-81 | lld:pubmed |
| pubmed-article:17638898 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17638898 | pubmed:meshHeading | pubmed-meshheading:17638898... | lld:pubmed |
| pubmed-article:17638898 | pubmed:meshHeading | pubmed-meshheading:17638898... | lld:pubmed |
| pubmed-article:17638898 | pubmed:meshHeading | pubmed-meshheading:17638898... | lld:pubmed |
| pubmed-article:17638898 | pubmed:meshHeading | pubmed-meshheading:17638898... | lld:pubmed |
| pubmed-article:17638898 | pubmed:meshHeading | pubmed-meshheading:17638898... | lld:pubmed |
| pubmed-article:17638898 | pubmed:meshHeading | pubmed-meshheading:17638898... | lld:pubmed |
| pubmed-article:17638898 | pubmed:meshHeading | pubmed-meshheading:17638898... | lld:pubmed |
| pubmed-article:17638898 | pubmed:meshHeading | pubmed-meshheading:17638898... | lld:pubmed |
