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pubmed-article:1762754pubmed:abstractTextWillebrand-factor antigen level and structure analysis, ristomycin-cofactor assay, beta-thromboglobulin and thromboxane metabolite estimations were performed in 22 patients with mixed connective tissue disease. High levels of Willebrand factor antigen and activity were detected in the presence of thrombocytopenia, previous thrombotic events, pulmonary vascular lesions and in the presence of circulating antiendothelial antibodies. Increased platelet activation was documented also in antibody positive cases and in thrombocytopenia. The alterations of endothelial and platelet functions may play important role in the development of vascular complications of mixed connective tissue disease.lld:pubmed
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pubmed-article:1762754pubmed:authorpubmed-author:ABELL LLLlld:pubmed
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pubmed-article:1762754pubmed:pagination2721-2, 2725lld:pubmed
pubmed-article:1762754pubmed:dateRevised2009-10-21lld:pubmed
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pubmed-article:1762754pubmed:articleTitle[Primary hemostasis in mixed connective tissue disease].lld:pubmed
pubmed-article:1762754pubmed:affiliationDebreceni Orvostudományi Egyetem, II. Belgyógyászati Klinika.lld:pubmed
pubmed-article:1762754pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1762754pubmed:publicationTypeEnglish Abstractlld:pubmed