| pubmed-article:17627282 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17627282 | lifeskim:mentions | umls-concept:C1333572 | lld:lifeskim |
| pubmed-article:17627282 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:17627282 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:17627282 | lifeskim:mentions | umls-concept:C0017715 | lld:lifeskim |
| pubmed-article:17627282 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:17627282 | lifeskim:mentions | umls-concept:C1523347 | lld:lifeskim |
| pubmed-article:17627282 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17627282 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:17627282 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:17627282 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:17627282 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:17627282 | pubmed:dateCreated | 2007-8-9 | lld:pubmed |
| pubmed-article:17627282 | pubmed:abstractText | C/EBPalpha is a key transcription factor indispensable for the onset of gluconeogenesis in perinatal liver. However, C/EBPalpha was already expressed in fetal liver, suggesting that the expression of C/EBPalpha alone does not account for the dramatic increase of the expression of metabolic genes, and hence an additional factor(s) is expected to function cooperatively with C/EBPalpha in perinatal liver. We show here that expression of Foxo1 was sharply increased in the perinatal liver and augmented C/EBPalpha-dependent transcription. Foxo1 bound C/EBPalpha via its forkhead domain, and Foxo1 bound to the promoter of a gluconeogenic gene, phosphoenolpyruvate carboxykinase (PEPCK), in a C/EBPalpha-dependent manner in vivo. Insulin inhibited the expression of PEPCK in a culture of fetal liver cells, and also the C/EBPalpha-dependent transcription enhanced by Foxo1. These results indicate that Foxo1 regulates gluconeogenesis cooperatively with C/EBPalpha, and also links insulin signaling to C/EBPalpha during liver development. | lld:pubmed |
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| pubmed-article:17627282 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17627282 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17627282 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17627282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17627282 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17627282 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:17627282 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:17627282 | pubmed:author | pubmed-author:FukamizuAkiyo... | lld:pubmed |
| pubmed-article:17627282 | pubmed:author | pubmed-author:OgataKazuhiro... | lld:pubmed |
| pubmed-article:17627282 | pubmed:author | pubmed-author:MiyajimaAtsus... | lld:pubmed |
| pubmed-article:17627282 | pubmed:author | pubmed-author:SekineKeisuke... | lld:pubmed |
| pubmed-article:17627282 | pubmed:author | pubmed-author:KojimaNobuhik... | lld:pubmed |
| pubmed-article:17627282 | pubmed:author | pubmed-author:ChenYen-RongY... | lld:pubmed |
| pubmed-article:17627282 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17627282 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:17627282 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:17627282 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17627282 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17627282 | pubmed:pagination | 3607-15 | lld:pubmed |
| pubmed-article:17627282 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:17627282 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17627282 | pubmed:articleTitle | Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development. | lld:pubmed |
| pubmed-article:17627282 | pubmed:affiliation | Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan. | lld:pubmed |
| pubmed-article:17627282 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17627282 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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