| pubmed-article:17626106 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17626106 | lifeskim:mentions | umls-concept:C0682455 | lld:lifeskim |
| pubmed-article:17626106 | lifeskim:mentions | umls-concept:C0035243 | lld:lifeskim |
| pubmed-article:17626106 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:17626106 | lifeskim:mentions | umls-concept:C0021743 | lld:lifeskim |
| pubmed-article:17626106 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:17626106 | lifeskim:mentions | umls-concept:C1326120 | lld:lifeskim |
| pubmed-article:17626106 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:17626106 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:17626106 | pubmed:dateCreated | 2007-8-30 | lld:pubmed |
| pubmed-article:17626106 | pubmed:abstractText | The respiratory tract is a major mucosal site for microorganism entry into the body, and type I interferon (IFN) and dendritic cells constitute a first line of defense against viral infections. We have analyzed the interaction between a model DNA virus, plasmacytoid dendritic cells, and type I IFN during lung infection of mice. Our data show that murine gammaherpesvirus 68 (gammaHV68) inhibits type I IFN secretion by dendritic cells and that plasmacytoid dendritic cells are necessary for conventional dendritic cell maturation in response to gammaHV68. Following gammaHV68 intranasal inoculation, the local and systemic IFN-alpha/beta response is below detectable levels, and plasmacytoid dendritic cells are activated and recruited into the lung with a tissue distribution that differs from that of conventional dendritic cells. Our results suggest that plasmacytoid dendritic cells and type I IFN have important but independent roles during the early response to a respiratory gammaHV68 infection. gammaHV68 infection inhibits type I IFN production by dendritic cells and is a poor inducer of IFN-alpha/beta in vivo, which may serve as an immune evasion strategy. | lld:pubmed |
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| pubmed-article:17626106 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17626106 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17626106 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17626106 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17626106 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17626106 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:17626106 | pubmed:author | pubmed-author:DurbinJoan... | lld:pubmed |
| pubmed-article:17626106 | pubmed:author | pubmed-author:MertzSara ESE | lld:pubmed |
| pubmed-article:17626106 | pubmed:author | pubmed-author:FlañoEmilioE | lld:pubmed |
| pubmed-article:17626106 | pubmed:author | pubmed-author:SimasJ... | lld:pubmed |
| pubmed-article:17626106 | pubmed:author | pubmed-author:JewellNancy... | lld:pubmed |
| pubmed-article:17626106 | pubmed:author | pubmed-author:Weslow-Schmid... | lld:pubmed |
| pubmed-article:17626106 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17626106 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:17626106 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17626106 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17626106 | pubmed:pagination | 9778-89 | lld:pubmed |
| pubmed-article:17626106 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17626106 | pubmed:meshHeading | pubmed-meshheading:17626106... | lld:pubmed |
| pubmed-article:17626106 | pubmed:meshHeading | pubmed-meshheading:17626106... | lld:pubmed |
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| pubmed-article:17626106 | pubmed:meshHeading | pubmed-meshheading:17626106... | lld:pubmed |
| pubmed-article:17626106 | pubmed:meshHeading | pubmed-meshheading:17626106... | lld:pubmed |
| pubmed-article:17626106 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17626106 | pubmed:articleTitle | Type I interferon inhibition and dendritic cell activation during gammaherpesvirus respiratory infection. | lld:pubmed |
