Linked Life Data

17625597

Source:http://linkedlifedata.com/resource/pubmed/id/17625597

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pubmed-article:17625597pubmed:abstractTextThe polycomb group (PcG) genes are epigenetic suppressors of gene expression that play an important role in development. In this study, we examine the role of Bmi-1 (B-cell-specific Moloney murine leukemia virus integration site 1) as a regulator of human epidermal keratinocyte survival. We identify Bmi-1 mRNA and protein expression in epidermis and in cultured human keratinocytes. Bmi-1 is located in the nucleus in cultured keratinocytes, and in epidermis it is expressed in the basal and suprabasal layers. Adenovirus-delivered Bmi-1 promotes keratinocyte survival and protects keratinocytes from stress agent-mediated cell death. This is associated with increased levels of cyclin D1 and selected cyclin-dependent kinases, and reduced caspase activity and poly(ADP-ribose) polymerase (PARP) cleavage. Bmi-1 may be involved in the maintenance of disease state, as Bmi-1 levels are elevated in transformed keratinocytes, skin tumors, and psoriasis. The presence of Bmi-1 in suprabasal non-proliferative cells of the epidermis and within a high percentage of cells within skin tumors suggests a non-stem cell pro-survival role for Bmi-1 in this tissue. Based on the suprabasal distribution of Bmi-1 in epidermis, we propose that Bmi-1 may promote maintenance of suprabasal keratinocyte survival to prevent premature death during differentiation. Such a function would help assure proper formation of the stratified epidermis.lld:pubmed
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pubmed-article:17625597pubmed:authorpubmed-author:KarigL MLMlld:pubmed
pubmed-article:17625597pubmed:authorpubmed-author:Balasubramani...lld:pubmed
pubmed-article:17625597pubmed:authorpubmed-author:EckertRichard...lld:pubmed
pubmed-article:17625597pubmed:authorpubmed-author:RorkeEllen...lld:pubmed
pubmed-article:17625597pubmed:authorpubmed-author:DimriGoberdha...lld:pubmed
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pubmed-article:17625597pubmed:authorpubmed-author:McCormickThom...lld:pubmed
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