| pubmed-article:17618273 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17618273 | lifeskim:mentions | umls-concept:C0237401 | lld:lifeskim |
| pubmed-article:17618273 | lifeskim:mentions | umls-concept:C0680340 | lld:lifeskim |
| pubmed-article:17618273 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:17618273 | lifeskim:mentions | umls-concept:C2699153 | lld:lifeskim |
| pubmed-article:17618273 | lifeskim:mentions | umls-concept:C1705165 | lld:lifeskim |
| pubmed-article:17618273 | lifeskim:mentions | umls-concept:C0597304 | lld:lifeskim |
| pubmed-article:17618273 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:17618273 | lifeskim:mentions | umls-concept:C2700061 | lld:lifeskim |
| pubmed-article:17618273 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:17618273 | pubmed:dateCreated | 2007-8-2 | lld:pubmed |
| pubmed-article:17618273 | pubmed:abstractText | Invasive cell migration through tissue barriers requires pericellular remodelling of extracellular matrix (ECM) executed by cell-surface proteases, particularly membrane-type-1 matrix metalloproteinase (MT1-MMP/MMP-14). Using time-resolved multimodal microscopy, we show how invasive HT-1080 fibrosarcoma and MDA-MB-231 breast cancer cells coordinate mechanotransduction and fibrillar collagen remodelling by segregating the anterior force-generating leading edge containing beta1 integrin, MT1-MMP and F-actin from a posterior proteolytic zone executing fibre breakdown. During forward movement, sterically impeding fibres are selectively realigned into microtracks of single-cell calibre. Microtracks become expanded by multiple following cells by means of the large-scale degradation of lateral ECM interfaces, ultimately prompting transition towards collective invasion similar to that in vivo. Both ECM track widening and transition to multicellular invasion are dependent on MT1-MMP-mediated collagenolysis, shown by broad-spectrum protease inhibition and RNA interference. Thus, invasive migration and proteolytic ECM remodelling are interdependent processes that control tissue micropatterning and macropatterning and, consequently, individual and collective cell migration. | lld:pubmed |
| pubmed-article:17618273 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17618273 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17618273 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17618273 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17618273 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17618273 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17618273 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17618273 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17618273 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17618273 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17618273 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17618273 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17618273 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:17618273 | pubmed:issn | 1465-7392 | lld:pubmed |
| pubmed-article:17618273 | pubmed:author | pubmed-author:StackM... | lld:pubmed |
| pubmed-article:17618273 | pubmed:author | pubmed-author:FriedlPeterP | lld:pubmed |
| pubmed-article:17618273 | pubmed:author | pubmed-author:TamEricE | lld:pubmed |
| pubmed-article:17618273 | pubmed:author | pubmed-author:WuYi IYI | lld:pubmed |
| pubmed-article:17618273 | pubmed:author | pubmed-author:GeigerJörgJ | lld:pubmed |
| pubmed-article:17618273 | pubmed:author | pubmed-author:WolfKatarinaK | lld:pubmed |
| pubmed-article:17618273 | pubmed:author | pubmed-author:LiuYueyingY | lld:pubmed |
| pubmed-article:17618273 | pubmed:author | pubmed-author:OverallChrist... | lld:pubmed |
| pubmed-article:17618273 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17618273 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:17618273 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17618273 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17618273 | pubmed:pagination | 893-904 | lld:pubmed |
| pubmed-article:17618273 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:meshHeading | pubmed-meshheading:17618273... | lld:pubmed |
| pubmed-article:17618273 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17618273 | pubmed:articleTitle | Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. | lld:pubmed |
| pubmed-article:17618273 | pubmed:affiliation | Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany. | lld:pubmed |
| pubmed-article:17618273 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17618273 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17618273 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:4323 | entrezgene:pubmed | pubmed-article:17618273 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17618273 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17618273 | lld:pubmed |
