| pubmed-article:17609371 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17609371 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:17609371 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:17609371 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:17609371 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:17609371 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:17609371 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:17609371 | lifeskim:mentions | umls-concept:C0083032 | lld:lifeskim |
| pubmed-article:17609371 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17609371 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:17609371 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:17609371 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:17609371 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:17609371 | lifeskim:mentions | umls-concept:C0205410 | lld:lifeskim |
| pubmed-article:17609371 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17609371 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17609371 | pubmed:issue | 28 | lld:pubmed |
| pubmed-article:17609371 | pubmed:dateCreated | 2007-7-11 | lld:pubmed |
| pubmed-article:17609371 | pubmed:abstractText | During many acute viral and bacterial infections, IL-7 receptor alpha-chain (IL-7Ralpha) is expressed on a subset of effector CD8 T cells that preferentially develop into long-lived memory CD8 T cells. These cells functionally require IL-7Ralpha, but it is unclear whether IL-7Ralpha acts mainly to induce their differentiation into memory cells or to sustain their long-term survival. To examine this question, IL-7Ralpha was constitutively overexpressed on all antigen-specific effector CD8 T cells during viral infection. Constitutive IL-7Ralpha expression had minimal effects on the numbers or function of effector and memory CD8 T cells formed. This indicated that IL-7Ralpha expression is not sufficient to drive memory cell development. In particular, the forced IL-7Ralpha expression did not rescue the killer cell lectin-like receptor G1 (KLRG1)(hi) short-lived effector CD8 T cells from death, showing that the majority of effector CD8 T cells die in an IL-7Ralpha-independent manner. Moreover, we found that, regardless of the ectopic expression of IL-7Ralpha, the KLRG1(hi), but not the KLRG1(lo) effector CD8 T cells, were unable to proliferate well to IL-7, which may be due to increased amounts of p27(kip) in KLRG1(hi) cells. Because IL-7 can destabilize p27(kip), this result suggested that KLRG1(hi) and KLRG1(lo) effector CD8 T cells naturally differ in their ability to transmit IL-7 signals. Altogether, these results reveal that IL-7Ralpha expression is permissive, but not instructive, to the creation of memory CD8 T cells. | lld:pubmed |
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| pubmed-article:17609371 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17609371 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17609371 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17609371 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17609371 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:17609371 | pubmed:author | pubmed-author:KaechSusan... | lld:pubmed |
| pubmed-article:17609371 | pubmed:author | pubmed-author:MorreMichelM | lld:pubmed |
| pubmed-article:17609371 | pubmed:author | pubmed-author:HandTimothy... | lld:pubmed |
| pubmed-article:17609371 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17609371 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:17609371 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:17609371 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17609371 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17609371 | pubmed:pagination | 11730-5 | lld:pubmed |
| pubmed-article:17609371 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
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| pubmed-article:17609371 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17609371 | pubmed:articleTitle | Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection. | lld:pubmed |
| pubmed-article:17609371 | pubmed:affiliation | Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. | lld:pubmed |
| pubmed-article:17609371 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17609371 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:17609371 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17609371 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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